Dr. Sujesh Sreedharan

Academic Qualifications

• PhD, SCTIMST, 2019
• MEE, Rice University, 2004.
• B.Tech, IIT Bombay, 2001.

Professional Record

• Engineer-G, SCTIMST, 2021-date
• Engineer-F, SCTIMST, 2017-21
• Engineer-E, SCTIMST, 2014-17
• Engineer-D, SCTIMST, 2010-14
• Engineer-C, SCTIMST, 2006-10
• Engineer-B, SCTIMST, 2004-06.
• Software Engineer, Motorola, India, 2001-2002.

Area of Interest

• Medical device development and testing.
• Medical Image processing

Collaboration

• Imaging Sciences and Interventional Radiology, SCTIMST - Vascular intervention, medical imaging, fNIRS
• Cardiology Department, SCTIMST - Cardiovascular devices
• Material Science Division, CSIR-NAL, Bengaluru - NiTi superelastic alloy based Cardiovascular devices
• Surgical Oncology, Regional Cancer Centre, Trivandrum - Voice prosthesis.

Current Activities

• Medical Devices: Computer aided design, Finite element analysis, In-vitro instrumentation and testing, Quality system documentation.
• Medical Imaging: Functional magnetic resonance imaging, Brain computer interfaces, fNIRS, Deep learning, brain connectivity.

Patents

• A delivery device with a release mechanism for deploying braided vascular devices. Patent. No: 497258.
• A delivery system with a thumb wheel drive for stent graft positioning and deployment. Patent. No: 437272.
• Implantable atrial septal occlusion device with left atrial disc having a low profile inter-twined centre. Patent. No: 437270.
• An asymmetric design of a stent with enhanced crimpability, having enclosing struts, for use in blood vessels. Patent. No: 437267.
• A self-expanding Flow Diversion Device with enhanced Kink Resistance and Radial Strength – International Patent in South Africa - 2021/02576.
• Implantable Atrial Septal Defect occlusion device with woven central section on left atrial flange. Patent. No: 489968. • International Patent in South Africa - 2020/03941.
• An improved stent for use in blood vessel with enhanced fixation. No. 429582
• A delivery device for positioning and deployment of stent grafts. No. 422625.
• A metallic stent for use in blood vessels. No: 357096.

Fellowships

• Rice University Graduate Fellowship, 2002-04, TX, USA.
• National Talent Scholarship, 1995-2001, India.

Membership

• Engineering in Medicine and Biology Society, IEEE - 2002
• Material Research Society of India.

On-going Projects

• Aortic Stent Graft - for endovascular treatment of thoracic aortic aneurysms.
• Atrial Septal Defect Occluder - for minimally invasive closure of ASD.
• Flow Diverter Stent - for catheterized treatment of cerebral aneurysms
• Voice Prosthesis - for voice restoration of laryngectomees
• Clot Retriever Stent - for treatment of acute ischemic stroke
• FNIRS based brain computer interface - for rehabilitation.

Projects Completed

• Coronary Stent (Co-I)
• Improved artificial heart valve (Co-I)
• Development of neurofeedback system using fMRI. (PI)
• Flow Diversion Stent - design optimization and prototyping (PI)
• Self-regulation of Broca's area in post-stroke aphasic patients using real-time fMRI based neurofeedback. (Co-PI)
• Titanium Nitride coatings for medical devices. (PI)

Training

• Project Management & Application of Risk Management to Medical Devices, ASCI
• ISO 13485 - Internal Auditing of Quality Management Systems
• ISO 17025 - Internal Auditing of Quality Management Systems
• Managing Innovation and Technology for Competitiveness, ASCI

Intellectual Property Disclosures

• Braided structure for use in blood vessels, Design No: 328451-001
• Implantable atrial septal defect occlusion device, Design No: 300221
• Implantable atrial septal defect occlusion device with woven central section on left atrial flange, Design No: 300220
• Stent crown for scaffolding blood vessels, Design No: 299425
• Stent crown for scaffolding blood vessels, Design No: 299424
• Stent crown for scaffolding blood vessels, Design No: 299423
• Stent crown for scaffolding blood vessels, Design No: 299422
• Stent crown for scaffolding blood vessels, Design No: 299421
• A stent for blood vessels, Design No: 241378
• A delivery device for positioning and deployment of stent grafts, Patent Appl No: 201741039555
• A self expanding flow diversion device with enhanced kink resistance and radial strength, Patent Appl No: 201841049649
• A braided cuff for preventing endoleaks in stent grafts, Patent Appl No: 201841049655
• A release mechanism for use in catheterized delivery of cardiovascular implantable device inside the body, Patent Appl No: 201941000952
• A voice prosthesis device with a one-way shunt valve, Patent Appl No: 201941003328
• An improved delivery device for deployment of stent grafts, Patent Appl No: 201941003745
• A braided stent, Patent Appl No: 201941022802

Team

• Muraleedharan CV.
• Ranjith G
• Rajeev A
• Subhashkumar MS
• Sivakumar KGV (Dr.)
• Subhash NN
• Saurabh S. Nair
• Anoop Gopinathan.
• Project Team - Krishnakumar S, Jijo Jerard, Anku S, Jnana NJ, Liji GV, Vivek PU, Amritha TS, Sujith V, Akhil, Mahesh, Narayanan, Sreehari, George.

Dissertations Supervised - M.Tech

• Real-time classification of fNIRS signal using deep learning.
• Finite element analysis of a coronary stent design.
• Finite element analysis of an EVAR stent design.
• Design and FEM analysis of a dental implant.
• Signal Processing of artificial heart valve sounds.
• Design and optimization of a flow diverter stent.
• Wireless energy transfer using resonant coils.
• Accelerated durability testing of coronary stents.
• Accelerated durability testing of vascular grafts.
• Functional MRI based real-time processing.
• Functional connectivity analysis of fMRI data.

Publications

Article

1. Naresh Kasoju, N. S. Remya, Renjith Sasi, S. Sujesh, Biju Soman, C. Kesavadas, C. V. Muraleedharan, P. R. Harikrishna Varma, Sanjay Behari, Digital health: trends, opportunities and challenges in medical devices, pharma and bio-technology, CSI Transactions on ICT, 2023, 11, 11-30, https://doi.org/10.1007/s40012-023-00380-3
2. Caleb Jones Shibu, Sujesh Sreedharan, KM Arun, Chandrasekharan Kesavadas, Ranganatha Sitaram, Explainable artificial intelligence model to predict brain states from fNIRS signals, Frontiers in Human Neuroscience, 2023, 16, https://doi.org/10.3389/fnhum.2022.1029784
3. Akhil, Jerard, J., Subhashkumar, M. S., Liji, G. V., Jnana, N. J., & Sujesh, S, Bubble Helmet for Non-Invasive Ventilation, Trends in Biomaterials & Artificial Organs, 34 (S2), 52-59, 2020, , https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/436
4. Sujesh S, Anuvitha C, Y. Vijay Raj, Sylaja PN, Kesavadas C, Ranganatha S, Self-regulation of Language Areas using Real-time Functional MRI in Stroke Patients with Expressive Aphasia, Brain Imaging and Behavior, 14, 1714-1730, 2020, , https://doi.org/10.1007/s11682-019-00106-7
5. Sujesh S, Arun KM, Sylaja PN, Kesavadas C, Ranganatha S, Functional Connectivity of Language Regions of Stroke Patients with Expressive Aphasia During Real-Time Functional Magnetic Resonance Imaging Based Neurofeedback, Brain Connectivity Vol. 9, No. 8 , 613-626, 2019, , https://doi.org/10.1089/brain.2019.0674
6. Subhash NN, Rajeev A, Sujesh S, Muraleedharan CV, TTK Chitra tilting disc heart valve model TC2: An assessment of fatigue life and durability, Proceedings of the Institution of Mechanical Engineers, Part H:Journal of Engineering in Medicine. 231(8): 758-765, 2017, , https://doi.org/10.1177/0954411917703676
7. Sujesh S., Ranganatha S., Joseph S. Paul, Kesavadas C, Brain Computer Interfaces for Neurorehabilitation, Critical Reviews in Biomedical Engineering, 2013, , DOI: 10.1615/CritRevBiomedEng.2014010697
8. S. Sujesh, A. Rajeev, S. J. Shenoy, P. R. Umashankar, and C. V. Muraleedharan, An automated data acquisition system for capturing physiological parameters during animal trials of artificial heart valves, International Journal of Biomedical Engineering and Technology 10(1), 70-83, 2012, , DOI: 10.1504/IJBET.2012.049326
9. Kesavadas C, Thomas B, Sujesh S, Radhakrishnan K et. al., Real-time functional MR imaging (fMRI) for presurgical evaluation of paediatric epilepsy, Pediatric Radiology, 2007, , https://doi.org/10.1007/s00247-007-0556-4

Conference proceedings

1. C. J. Shibu, Sujesh S, Arun KM and C. Kesavadas, Comparison of classification performance of handpicked, handcrafted and automated-features for fNIRS-BCI system, 5th International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS), Okinawa, Japan, 2020,
2. Sujesh S, Neurofeedback and its applications, IBRO-APRC School, Trivandrum, 2019,
3. Sujesh S, Real-time fMRI based Neurofeedback and Brain Connectivity, Brain CONN, Trivandrum, 2018,
4. Sujesh S, Arun KM, Sylaja PN, Ranganatha S, Kesavadas C, Functional Connectivity changes during real-time fMRI based Neurorehabilitation of post stroke aphasic patients, ISMRM, Paris., 2018,
5. Sujesh S, Anuvitha C, Y.Vijay Raj, Sylaja P.N, Kesavadas C, Ranganatha S., Self-Regulation of Broca's and Wernicke's areas using real-time functional MRI in stroke patients with expressive Aphasia, Real-time functional imaging and Neurofeedback Conference, Japan, 2017,
6. Sujesh S, Titanium Nitride Coatings for Medical Devices, International Workshop on Coatings and Surfaces for Biomedical Engineering, IIT Madras, India, 2014,
7. Sujesh S, Anuvitha C, Arathy J.S, Sylaja P.N, Kesavadas C, Ranganatha S, Self-Regulation of Broca's area using real time functional MRI in Stroke patients with expressive Aphasia - A Pilot Study, Annual Conference of Indian Society for Neuroradiology, India, 2014,
8. Sujesh S, Anuvitha C, Arathy J.S, Annamma George, Sylaja P.N, Kesavadas C, Ranganatha S, Self-Regulation of Broca's area using real time functional MRI in Stroke patients with expressive Aphasia - Study Hypothesis & Methodology, Neurobionics, JIPMER, India, 2013,
9. Abhishek M., Sujesh S., Kesavadas C, Designing a Brain Computer Interface using real-time functional MRI, National Conference on Brain and Consciousness, ISI Kolkata, 2013,
10. Rajeev A, Sivakumaran N, Sujesh S, Muraleedharan CV, A linear after-load model for a cardio-vascular pulse duplicator, International Conference on Advances in Computing, Communications and Informatics, ACM, pp. 493497, 2012,
11. Ashish G, Sujesh S, Mini M.S, Anakha K.B.L, Ashalatha R, Kesavadas C, Statistical parametric mapping of EEG correlated fMRI data to detect epileptic foci, Biomedical Systems, Signals and Images, IIT Chennai, 2012,
12. Sujesh S, Rajeev A, Praveen MS, Bipin G, Rufus R, Muraleedharan CV, An Automated Instrumentation System for Expansion and Deployment Characterization of Tubular Stent Devices, International Conference on System Dynamics and Control, 2010,
13. Radhakrishnan PV, Sujesh S, Muraleedharan CV, Finite element analysis of sewing ring interface for studying the load transfer during closure of mechanical heart valves, International Conference on System Dynamics and Control, 2010,
14. Rajeev A, Muraleedharan VC, Ranjith G, Sujesh S, Muraleedharan CV, A data acquisition system for accelerated durability testing of heart valves, Control Instrumentation and Systems Conference, 2008,
15. Sujesh S, Rajeev A, Muraleedharan CV, A Virtual Instrumentation (VI) based system to acquire physiological parameters during preclinical animal trials of a prosthetic heart valve device, VIMANTRA, National Instruments Conference, India, 2008,
16. Muraleedharan CV, Sujesh S, Shankarkumar R, Bhuvaneshwar GS, Titanium nitride in a new tilting disc heart valve model, VIII World Biomaterial Congress, Amsterdam, 2008,
17. Naveen Kumar KU, Sujesh S, Nandakumar CG, Muraleedharan CV, A methodology for studying the characteristics of expansion of stent like structures in a hyper elastic artery model, Proceeding of International Conference Modeling and Simulation, India, 2007,