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Dr. Madhusoodanan U. K.

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Contact Information

Address:

Dr. Madhusoodanan U. K.
Additional Professor
Biochemistry

Phone number:

4478(O)

People - Biochemistry

Dr. Madhusoodanan U. K.

Academic Qualifications

  • PhD-Department of Biochemistry, Indian Institute of Science, Bangalore, 2009
  • MSc-Medical Biochemistry, KMC Manipal, Manipal University (MAHE), 2002
  • BSc-Microbiology, Kannur University, 1999

Professional Record

  • Additional Professor, Department of Biochemistry, SCTIMST, January 2024-
  • Associate Professor, Department of Biochemistry, SCTIMST, January 2021-December 2023
  • Assistant Professor - Department of Biochemistry, SCTIMST, October 2017-December 2020
  • Research Scientist - Molecular Oncology, MVRCCRI, Calicut, 2017
  • Post Doctoral fellow - IFOM-The FIRC Institute of Molecular Oncology, MIlan, Italy- 2009-2016

Honors

  • JRF-NET CSIR and ICMR (2003)
  • Invited speaker in international conferences

Area of Interest

  • Genetic and Molecular basis of rare inherited disorders
  • Circulating exosomal-miRNAs as disease indicators for neurodegenerative diseases
  • Development of biochemical assays for rare neurodegenerative diseases diagnosis

Fellowships

  • Post doctoral fellowship funded by European Research Council (ERC-2009-StG ERC-SG) - Regulatory mechanisms coordinating replication integrity and intra-S repair
  • Welcome trust Visiting fellow (February to April 2010), NCBR, Masaryk University, Brno, Czech Republic

Membership

  • Life member, Indian Society of Human Genetics (ISHG)
  • Executive Committee Member, Indian Society for Extracellular Vesicles (InSEV)
  • Life member, Society of Biological Chemists (SBC-India)
  • Life member, Academy of Cardiovascular Sciences

On-going Projects

  • Principal Investigator: Absolute measurement of Glucocerobrosidase activity for monitoring lysosomal dysfunction in Parkinsons disease-ICMR (2023-2025)
  • Co-PI: Contemporary outcomes in cardiac channelopathies guided by Genotype-based management-ICMR (2021-2025)
  • Co-I: Prognostic value of circulating microRNAs in Heart Failure-ICMR (2021-2023)
  • Co-I: ICMR-Center for Advanced Research and Excellence (CARE) in heart failure-ICMR (2019-2024)
  • Co-I: Genetic Architecture of Parkinsons disease-The Michael J. Fox Foundation (2019-2022)
  • Co-PI: A whole exome sequencing study … in Moyamoya disease in the Indian population-ICMR (2023-2025)

Projects Completed

  • Principal Investigator: Identification and characterization of exosomal proteins in Parkinsons Disease Patients-ICMR (2021-2024)
  • Principal Investigator: Detection of Circulating Exosomal-Ubiquitinated Proteins in Parkinsons Disease-Seed Fund-SCTIMST (2019-2021)
  • Co-PI: Establishment of A Biorepository of Epilepsy and Investigating the Relation of Multidrug Transporter Polymorphism with Fetal Malformations Based on The Repository -DBT (2017-2020)
  • Co-Invest: Development of real time RT-PCR assay for detection of SARS-CoV2-TDF fund-SCTIMST (2020-2021)

Training

  • Four days Training in Laboratory Quality Management System (IA & QMS as per ISO15189) accredited by National Accreditation Board for Education and Training (NABET), Quality council of India

Organisational Activities

  • Organizing committee member: Biochemistry Talks- Department of Biochemistry, SCTIMST
  • Scientific Affairs Committee member: 39th Annual Conference of Indian Association for Cancer Research (IACR-2020) at Trivandrum on 5th -7th February 2020
  • Faculty and moderator for a session in The Heart Failure Conflux, organised by the Heart Failure Assiciation of India

Team

  • PhD Students: Priya Nataraj, Sangeetha Suresh

Presentations

  • National Symposium on Mass Spectrometry Based Lipidomics in Disease Biology" held from 21-22 February 2025 at BRIC-RGCB, Thiruvananthapuram
  • Annual Investigators Meeting-Global Parkinsons Genetics Program (GP2), Copenhagen, Denmark on 24-26th August, 2023
  • 5th Chromosome Stability Meeting, Dec 14-18, 2022, IISER, Trivandrum
  • 39th Annual Conference of Indian Association for Cancer Research (IACR-2020) at Trivandrum on 5th -7th February 2020.
  • 10th DAE-BRNS Life Science Symposium-2019 (LSS-2019), BARC, Mumbai, March 28-30, 2019
  • Chromosome Stability 2018 meeting, December 14-17, 2018, JNCASR, Bangalore
  • 10th Young Investigator Meeting (YIM 2018), Mar 5-9, 2018, Trivandrum
  • Indo-French Conference (Indo-French Centre for Promotion of Advanced Research, IFCPAR/CEFIPRA), December 4-5, 2017, Bangalore.

Invited talks

  • CME on the occasion of World Microbiome Day, organized by Department of Medical Microbiology & Department of Medical Biochemistry, AKG Co-operative Institute of Health Sciences, Kannur on June 27, 2022
  • Emerging Trends and Fronters in Applied Microbiology and Biotechnology, organised by St. Pius X College, Rajapuram, Kasaragod on March 10th 2022 (Online)
  • Emerging trends in Neurotherapeutics, organized by at the department of Biochemistry, St. Thomas College, Palai on December 15th, 2021 (online)
  • Special lecture on Basic Concepts of Diet and Nutrition, Department of Yoga Studies, Central University of Kerala, October 2020, online.
  • National Workshop Biovista-2020, Department of Biochemistry, Malankara Catholic College, Kaliakkavilai, Tamil Nadu, on February 4th, 2020.
  • National Symposium on Advances in Biosciences(SEIB 2019), Inter University Centre for Evolutionary and Integrative Biology (iCEIB) of the University of Kerala, April 27, 2019
  • National seminar on Omics approaches in Biotechnology at the department of biotechnology, Govt college, Kariavattom on February 15th, 2019
  • National seminar on New horizons in cancer treatment and prevention: from bench to bedside, Mar 16-17, SN college, Kollam, 2018
  • Cardio-vascular pathology update, Mar 11-12, SCTIMST, 2018

No. of Publications

  • 38

Publications

Article

  1. Fasaludeen A, Jose M, Aswathi U, Prasannakumar S, Banerjee M, Sundaram S, Madhusoodanan Urulangodi, Radhakrishnan A, Menon RN , A real-world comparison between the diagnostic yield of trio-whole exome sequencing and proband-only targeted exome sequencing in complex childhood epilepsy, Seizure, 2025, 2025 Apr 1;129:51-54, https://doi.org/10.1016/j.seizure.2025.03.020
  2. Harikrishnan S, Koshy L, Ganapathi S, Jeemon P, Ramya Das NK, Madhusoodanan Urulangodi, Madhuma M, Vysakh Y, Subran A, Lakshmikanth LR , Clinical exome sequencing unravels the diverse spectrum of genetic heterogeneity and genotype-phenotype correlations in hypertrophic cardiomyopathy, Int J Cardiol , 2024, 2024 Jun 14:132273, https://doi.org/10.1016/j.ijcard.2024.132273
  3. Aishwarya Babu, Achanya S Jayan, Anjali Sethumadhavan, Geetha Mandagini, Cibin T Raghavan, Srinivas Gopala, Syam Krishnan*, Madhusoodanan Urulangodi*, An improved Glucocerebrosidase assay for accurate prediction of lysosomal dysfunction: exemplified by its relevance in Parkinsons Disease, Ind J Clin Biochem, 2024, , https://doi.org/10.1007/s12291-024-01234-8
  4. Asha Kishore, Marc Sturm, Kanchana Soman Pillai, Christopher Hakkaart, Divya Kalikavil Puthanveedu, Madhusoodanan Urulangodi, Syam Krishnan, Ashwin Ashok Kumar-Sreelatha, Roopa Rajan, Pramod Kumar Pal, Ravi Yadav, Gangadhara Sarma, Nicolas Casadei, Thomas Gasser, Peter Bauer, Olaf Riess, Manu Sharma, Resequencing the complete SNCA locus in Indian patients with Parkinsons disease., npj Parkinson’s Disease, 2024, 10(1):85, https://doi.org/10.1038/s41531-024-00676-4
  5. Fasaludeen A, McTague A, Jose M, Banerjee M, Sundaram S, Madhusoodanan UK, Radhakrishnan A, Menon RN, Genetic variant interpretation for the neurologist - A pragmatic approach in the next-generation sequencing era in childhood epilepsy, Epilepsy Res., 2024, 201:107341, https://doi.org/10.1016/j.eplepsyres.2024.107341
  6. Deepthy Chandran, Syam Krishnan, Madhusoodanan Urulangodi*, Srinivas Gopala*, Exosomal microRNAs in Parkinsons disease: insights into biomarker potential and disease pathology, Neurological Sciences, 2024, , https://doi.org/10.1007/s10072-024-07439-2
  7. Anand Binu, Easwer HV, Prakash Nair, Antony Stanley, Biren Khimji Patel, Madhusoodanan Urulangodi, Geetha Mandagini, Tania Jose , Role of Copeptin in predicting Post operative Hyponatremia and Hypernatremia in patients undergoing endoscopic pituitary adenoma surgery, Neurosurgery, 2024, March 29, 2024, https://doi.org/10.1227/neu.0000000000002927
  8. Vasu MM, Koshy L, Ganapathi S, Jeemon P, Madhusoodanan U, Gopala S, Greeva P, Anitha A, Reethu S, Divya P, Shamla S, Sumitha K, Madhavan M, Vineeth CP, Kochumoni R, Harikrishnan S, Identification of novel endogenous control miRNAs in heart failure for normalization of qPCR data, Int J Biol Macromol, 2024, 2024 Jan 27:129714
  9. Pravi Vidyadharan, Santhi CKV, Anjali Sethumadhavan, Srinivas Gopala, Cibin T Raghavan, Madhusoodanan Urulangodi*, Functional assessment of DNA extraction methods from frozen human blood samples for Sanger sequencing analysis, Cellular and Molecular Biology, 2023, 69(8): 25-33, http://dx.doi.org/10.14715/cmb/2023.69.8.4
  10. Aishwarya Babu, Madhusoodanan Urulangodi*, Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain, Genome Instability & Disease, 2023, , https://doi.org/10.1007/s42764-023-00110-8
  11. Rudrabhatla PK, Divya KP, Alfiya F, Ramshekhar N. Menon, Ajith Cherian, Madhusoodanan Urulangodi, Soumya Sundaram, Generalised stiffness in hereditary hyperekplexia responsive to trihexyphenidyl: a novel finding., Clinical Pediatrics, 2023, Oct 29:99228231203300., https://doi.org/10.1177/00099228231203300
  12. Asish Vijayaraghavan, Madhusoodanan Urulangodi, Karthika Ajit, Soumya Sundaram, Syam Krishnan, Movement disorders in GRIA2-related disorder - expanding the genetic spectrum of developmental dyskinetic encephalopathy., Movement Disorders Clinical Practice, 2023, 10(8):1222-1224, https://doi.org/10.1002/mdc3.13797
  13. Soumya Krishnamoorthy, Gurpreet Singh, Sapna Erat Sreedharan, Deepa Damayanthi, Srinivas Gopala, Madhusoodanan UK, Sylaja PN, Soluble ST2 Predicts Poor Functional Outcome in Acute Ischemic Stroke Patients., Cerebrovasc Dis Extra, 2023, 13(1):33-40, https://doi.org/10.1159/000529512
  14. Karthika Ajit, Srutji S Nair, Sethu Madhavan Anjali, Pravi Vidyadharan, Madhusoodanan Urulangodi, Ramshekhar N Menon, Soumya Sundaram, A genotype-phenotype description in two Indian patients: broadening the spectrum in VRK1-related complex motor disorders., Neurology and Clinical Neuroscience, 2023, , https://doi.org/10.1111/ncn3.12694
  15. Krishnamoorthy S, Sylaja PN, Sreedharan SE, Singh G, Damayanthi D, Gopala S, Madhusoodanan UK, Ramachandran H.J, Biomarkers predict hemorrhagic transformation and stroke severity after acute ischemic stroke., J Stroke Cerebrovasc Dis, 2023, 32(1):106875, https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106875
  16. Bhavya B, Anand CR, Madhusoodanan Urulangodi, Sreelakshmi K, Deepti AN, Girish RM, Krishnakumar K, Easwer HV, Srinivas G, The mutant isocitrate dehydrogenase 1 product, 2-hydroxyglutarate, activates MutT homolog 1 in glioma cells via the augmentation of reactive oxygen species levels, World Academy of Sciences Journal, 2022, , https://doi.org/10.3892/wasj.2022.174
  17. F. Alfia, Manna Jose, Soumya V Chandrasekharan, Soumya Sundaram, Madhusoodanan Urulangodi, Bejoy Thomas, Ashalatha Radhakrishnan, Moinak Banerjee, Ramshekhar N Menon, C12orf57 pathogenic variants: a unique cause of developmental encephalopathy in a south Indian child., Journal of Genetics, 2022, 101 (3), https://doi.org/10.1007/s12041-022-01371-0
  18. Linda Koshy, Jeemon Panniyammakal, Sanjay Ganapathi, Madhuma M, Madhusoodanan Urulangodi, Meenakshi Sharma, Harikrishnan Sivadasanpillai, Association of South Asian-specific MYBPC3Δ25bp deletion polymorphism and cardiomyopathy: A systematic review and meta-analysis., Meta Gene, 2021, 28, 100883, https://doi.org/10.1016/j.mgene.2021.100883
  19. Bhavya B, Easwer HV, Vilanilam GC, Anand CR, Sreelakshmi K, Madhusoodanan Urulangodi, et al.,, MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha, Life Sci., 2021, 2021 Jan 1;264:118673., https://doi.org/10.1016/j.lfs.2020.118673
  20. Anja Waizenegger, Madhusoodanan Urulangodi, Carl Lehmann, Reyes TAC, Saugar I, Tercero JA, Szakal B, Branzei D., Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity, Nature Communications, 2020, 11, 5746., https://doi.org/10.1038/s41467-020-19503-4
  21. Madhusoodanan Urulangodi*, Abhishek Mohanty, DNA Damage Response and Repair Pathway Modulation by Non-Histone Protein Methylation: Implications in Neurodegeneration, J Cell Commun Signal, 2020, 14 (1):31-45, 2020, https:/doi.org/10.1007/s12079-019-00538-2
  22. Rajan R, Divya KP, Kandadai RM, Yadav R, Satagopam VP, Madhusoodanan UK et al., Lux-GIANT Consortium, Genetic Architecture of Parkinsons Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinsons Disease Research, Front. Neurol, 2020, 11:524, https://doi.org/10.3389/fneur.2020.00524
  23. Bhavya B, Anand CR, Madhusoodanan UK, Rajalakshmi P, Krishnakumar K, Easwer HV, Deepti AN, Gopala S, To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma., Cell Mol Neurobiol., 2020, , https://doi: 10.1007/s10571-019-00730-3
  24. Sebesta M, Madhusoodanan Urulangodi, Stefanovie B, Szakal B, Pacesa M, Lisby M, Branzei D, Krejci L, Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains, Nucleic Acids Res., 2017, 45(1):215-230, https://doi.org/10.1093/nar/gkw882
  25. Madhusoodanan Urulangodi, Sebesta M, Menolfi D, Szakal B, Sollier J, Sisakova A, Krejci L, Branzei D, Local Regulation of the Srs2 Helicase by the SUMO-like Domain Protein Esc2 Promotes Recombination at the site of Stalled Replication., Genes and Development, 2015, 29 (19); 2067-2080, https://doi.org/10.1101/gad.265629.115
  26. Madhusoodanan Urulangodi, Szakal B, Branzei D, SUMO-Mediated Local Control of Recombination, Cell Cycle, 2016, 15(2); 160-161, https:// doi.org/10.1080/15384101.2015.1118918
  27. Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, Rajakumara E, Fumasoni M, Bermejo R, Jentsch S, Branzei D, DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity, EMBO J, 2014, 33(4):327-340, https://doi.org/10.1002/embj.201387425
  28. Madhusoodanan Urulangodi, Dhanaraju R, Gupta K, Roy RP,Bujnicki J, Rao DN, Asymmegric DNA Methylation by Dimeric EcoP15I DNA Methyltransferase, Biochimie, 2016, 128-129; 70-82, https://doi.org/10.1016/j.biochi.2016.07.006
  29. Madhusoodanan UK, Rao DN, Diversity of DNA methyltransferases that recognize asymmetric target sequences, Crit Rev Biochem Mol Biol, 2010, 45(2):125-145., https://doi.org/10.3109/10409231003628007
  30. Bist P*, Madhusoodanan UK*, Rao DN., A mutation in the Mod subunit of EcoP15I restriction enzyme converts the DNA methyltransferase to a site-specific endonuclease, J Biol Chem, 2007, 282(6):3520-30, https://doi.org/10.1074/jbc.M603250200
  31. Banerjee D, Jacob J, Kunjamma G, Madhusoodanan UK, Ghosh S., Measurement of urinary hydrogen peroxide by FOX-1 method in conjunction with catalase in diabetes mellitus--a sensitive and specific approach, Clin Chim Acta, 2004, 350(1-2):233-6., https://doi.org/10.1016/j.cccn.2004.07.026
  32. Banerjee D, Madhusoodanan UK, Nayak S, Jacob J, Urinary hydrogen peroxide: a probable marker of oxidative stress in malignancy, Clin Chim Acta, 2003, 334(1-2):205-9, https://doi.org/10.1016/s0009-8981(03)00236-5
  33. Banerjee D, Madhusoodanan UK, Sharanabasappa M, Ghosh S, Jacob J, Measurement of plasma hydroperoxide concentration by FOX-1 assay in conjunction with triphenylphosphine, Clin Chim Acta, 2003, 337(1-2):147-52, https://doi.org/10.1016/j.cccn.2003.08.004
  34. Banerjee D, Kumar AP, Kumar B, Madhusoodanan UK, Nayak S, Jacob J, Determination of absolute hydrogen peroxide concentration by spectrophotometric method, Current Science, 2002, 83 (10);1193-1194, https://www.jstor.org/stable/24106468
  35. Jose Jacob, Deepthi Chandran, Ranjana Sasidharan, Leena Kuruvila, U K Madhusoodanan, Nivedita L. Rao and Dibyajyoti Banerjee, Chlortetracycline, a fluorescent probe for pH of calcium stores in cells, Current Science, 2002, 84 (5) 671-674., https://www.jstor.org/stable/24108502

Review

  1. Vasu MM, Koshy K, Ganapathi G Panniyammakal J, Madhusoodanan Urulangodi, Srinivas G, Harikrishnan S , Diagnostic and Prognostic Relevance of Circulating MicroRNAs in Heart Failure, Heart Failure Journal of India, 2025, 3(1):p 17-36, January-April 2025, https://doi.org/10.4103/HFJI.HFJI_5_25