Dr. Sachin J. Shenoy

Academic Qualifications

• Master of Veterinary Science; College of Veterinary & Animal Sciences, Kerala Agricultural University, Mannuthy, Thrissur-680 651; 2004 .
• Bachelor of Veterinary Science & Animal Husbanbry; College of Veterinary & Animal Sciences, Kerala Agricultural University, Mannuthy, Thrissur-680 651; 2001.

Professional Record

• Scientist - C, D, E,F ; Division of In-vivo Models & Testing, Biomedical Technology Wing, SCTIMST; 09/08/2006 - Till date.
• Veterinary Surgeon; Division of In-vivo Models & Testing, Biomedical Technology Wing, SCTIMST; 28/09/2005 - 04/08/2006.
• Veterinary Surgeon; Division of Vivarium, Biomedical Technology Wing, SCTIMST; 16/03/2005 - 25/09/2005.
• Teaching Assistant; University Livestock Farm, Kerala Agricultural University, Mannuthy Thrissur;15/12/2004 - 10/03/2005.
• Veterinary Surgeon; Division of Vivarium, Biomedical Technology Wing, SCTIMST; 13/12/2002 - 03/10/2003.

Honors

• DST-IIPA Silver Medal for having secured the second position among the participants in the 9th Foundation Training Programme for Scientists and Technologists sponsored by Department of Science and Technology at Indian Institute of Public Administration, New Delhi in 2010.

Area of Interest

• Experimental Animal Surgery, Anaesthesia and Perioperative Acute Care.

Current Activities

• Assistance in conduct of animal studies for proof of concept and preclinical testing of medical devices like coronary stents, heart valves, left ventricular assist devices, vascular grafts and dental composites in large animal models.
• Routine management of Large Animal Facility, DIMT.

Membership

• Member, Indian Veterinary Association
• Life Member, Society for Biomaterials and Artificial Organs - India.
• Life member, Laboratory Animal Science Association of India.
• Life member, Indian Society for Veterinary Surgery.

On-going Projects

• Principal Investigator: Over Head Fund (OHF) project "Characterization and Documentation of base line reference data of inhouse bred Ankamali Swine for application in Biomedical Research".

Team

• Ms Smitha P, Technical Assistant (Anaesthesia).
• Mr Prem Mohan, Technical Assistant (Lab) .
• Mr Manoj Kumar K, Animal Caretaker.
• Mr Biju V, Animal Handler.

No. of Publications

• 42

प्रकाशन

Article

1. Vijayan VM, Shenoy SJ, Victor SP, Muthu J., Stimulus responsive nanogel with innate near IR fluorescent capability for drug delivery and bioimaging. , Colloids and Surfaces B: Biointerfaces. , 2016, Oct 1;146:84-96., https://doi.org/10.1016/j.colsurfb.2016.05.059
2. Nair RS, Sobhan PK, Shenoy SJ, Prabhu MA, Rema AM, Ramachandran S, C Geetha S, V Pratheesh K, Mony MP, Raj R, Anilkumar TV., A porcine cholecystic extracellular matrix conductive scaffold for cardiac tissue repair., Journal of Biomedical Materials Research Part B: Applied Biomaterials., 2022, Mar 19., https://doi.org/10.1002/jbm.b.35058
3. Dayamon D. M., Sachin J. S., Vineeth M. R., Umashankar P. R., Electroencephalographic Evaluation of Thiopentone and Propofol Anaesthesia in Dogs. JIVA., JOURNAL OF INDIAN VETERINARY ASSOCIATION, KERALA, 2021, Dec 19 (3) : 27-36., DOI: 10.55296/JIVA/19.3.2021.27-36.
4. Saraswathy A, Nazeer SS, Nimi N, Santhakumar H, Suma PR, Jibin K, Victor M, Fernandez FB, Arumugam S, Shenoy SJ, Varma PR., Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe., Scientific Reports., 2021, Sep 15;11(1):1-1., https://www.nature.com/articles/s41598-021-97808-0
5. Mony MP, Shenoy SJ, Raj R, Geetha CS, Pratheesh KV, Nair RS, Purnima C, Anilkumar TV., Gelatin-Modified Cholecyst-Derived Scaffold Promotes Angiogenesis and Faster Healing of Diabetic Wounds., ACS Applied Bio Materials., 2021, Mar 10;4(4):3320-31., https://doi.org/10.1021/acsabm.0c01648
6. Raj R, Shenoy SJ, Mony MP, Pratheesh KV, Nair RS, Geetha CS, Sobhan PK, Purnima C, Anilkumar TV., Surface Modification of Polypropylene Mesh with a Porcine Cholecystic Extracellular Matrix Hydrogel for Mitigating Host Tissue Reaction., ACS Applied Bio Materials., 2021, Mar 10;4(4):3304-19., https://doi.org/10.1021/acsabm.0c01627
7. Harikrishnan VS, Shenoy SJ, Ranaraj VR, Sukhija S, Oloyo AK., A report on less-severe, long-duration persistent hind-limb ischemia surgical rabbit model., Journal of the Hellenic Veterinary Medical Society., 2021, 72(4):3455-62., https://doi.org/10.12681/jhvms.29395
8. Sathee D, Shenoy SJ, Anil A. Sabareeswaran A, Lissy Kalliyana Krishnan., Combinatorial Application of Hyaluronic Acid and Curcumin-Albumin Conjugate for Cartilage Repair in TNF Induced Inflammation in Rabbit Knee Joint., Archives of Clinical and Biomedical Research., 2021, 5:519-37., https://www.fortunejournals.com/articles/combinatorial-application-of-hyaluronic-acid-and-curcuminalbumin-conjugate-for-cartilage-repair-in-tnf-alpha-induced-inflammation-.html
9. Venugopal B, Shenoy SJ, Mohan S, Anil Kumar PR, Kumary TV., Bioengineered corneal epithelial cell sheet from mesenchymal stem cells- A functional alternative to limbal stem cells for ocular surface reconstruction., Journal of Biomedical Materials Research Part B: Applied Biomaterials., 2020, Apr;108(3):1033-45., https://doi.org/10.1002/jbm.b.34455
10. Nair RV, Nair LV, Govindachar DM, Santhakumar H, Nazeer SS, Rekha CR, Shenoy SJ, Periyasamy G, Jayasree RS., Luminescent Gold Nanorods To Enhance the Near???Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy:, Experimental and Theoretical Approach. Chemistry???A European Journal., 2020, Mar 2;26(13):2826-36., https://doi.org/10.1002/chem.201904952
11. Anitha R, Vaikkath D, Shenoy SJ, Nair PD., Tissue engineered islet like cell clusters generated from adipose tissue derived stem cells on three dimensional electrospun scaffolds can reverse diabetes in an experimental rat model and the role of porosity of scaffolds on cluster differentiation., Journal of Biomedical Materials Research Part A., 2020, Mar;108(3):749-59., https://doi.org/10.1002/jbm.a.36854
12. Subha S, Shenoy SJ, Anil A, Sabareeswaran A, Deepthi AN, Krishnan LK., Fibrin hydrogel aided cardiac progenitor cell delivery enhances regenerative tendency in myocardial infarct model., Archives of Clinical and Biomedical Research., 2020, 4(5):513-41., https://www.fortuneonline.org/articles/fibrin-hydrogel-aided-cardiac-progenitor-cell-delivery-enhances-regenerative-tendency-in-myocardial-infarct-model.html
13. Jibin K, Prasad JS, Saranya G, Shenoy SJ, Maiti KK, Jayasree RS., Optically controlled hybrid metamaterial of plasmonic spiky gold inbuilt graphene sheets for bimodal imaging guided multimodal therapy., Biomaterials Science., 2020, 8(12):3381-91., https://doi.org/10.1039/D0BM00312C
14. Suma PR, Padmanabhan RA, Telukutla SR, Ravindran R, Velikkakath AK, Dekiwadia CD, Paul W, Shenoy SJ, Laloraya M, Srinivasula SM, Bhosale SV., Paradigm of Vanadium pentoxide nanoparticle-induced autophagy and apoptosis in triple-negative breast cancer cells., BioRxiv., 2019, Jan 1:810200., doi: https://doi.org/10.1101/810200
15. Vijayan VM, Beeran AE, Shenoy SJ, Muthu J, Thomas V., New magneto-fluorescent hybrid polymer nanogel for theranostic applications., ACS Applied Bio Materials., 2019, Jan 9;2(2):757-68., https://doi.org/10.1021/acsabm.8b00616
16. Nazeer SS, Saraswathy A, Shenoy SJ, Jayasree RS., Fluorescence spectroscopy as an efficient tool for staging the degree of liver fibrosis: an in vivo comparison with MRI., Scientific reports., 2018, Jul 20;8(1):1-1., https://www.nature.com/articles/s41598-018-29370-1
17. Nimi N, Saraswathy A, Nazeer SS, Francis N, Shenoy SJ, Jayasree RS., Multifunctional hybrid nanoconstruct of zerovalent iron and carbon dots for magnetic resonance angiography and optical imaging: an in vivo study., Biomaterials., 2018, Jul 1;171:46-56., https://doi.org/10.1016/j.biomaterials.2018.04.012
18. Santhakumar H, Nair R, Philips DS, Shenoy SJ, Thekkuveettil A, Ajayaghosh A, Jayasree R, Real time imaging and dynamics of hippocampal Zn2+ under epileptic condition using a ratiometric fluorescent probe., Scientific reports., 2018, Jun 13;8(1):1-1., https://www.nature.com/articles/s41598-018-27029-5
19. Chandran S, Shenoy SJ, Nair RP, Varma HK, John A., Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model., Colloids and Surfaces B: Biointerfaces., 2018, Mar 1;163:346-54., https://doi.org/10.1016/j.colsurfb.2017.12.048
20. Unnikrishnan M, Umashankar PR, Viswanathan S, Savlania A, Joseph R, Muraleedharan CV, Agrawal V, Shenoy SJ, Krishnan LK, Mohanan PV, Sabareeswaran A., Preclinical evaluation of hydrogel sealed fluropassivated indigenous vascular prosthesis., The Indian Journal of Medical Research., 2017, Nov;146(5):646, https://doi.org/10.4103%2Fijmr.IJMR_1933_15
21. Umashankar PR, Sabareeswaran A, Shenoy SJ., Long term healing of mildly cross linked decellularized bovine pericardial aortic patch., Journal of Biomedical Materials Research Part B: Applied Biomaterials., 2017, Oct 1;105(7):2145-52., https://doi.org/10.1002/jbm.b.33755
22. Vijayan VM, Shenoy SJ, Muthu J., Octreotide-conjugated fluorescent PEGylated polymeric nanogel for theranostic applications., Materials Science and Engineering: C., 2017, Jul 1;76:490-500., https://doi.org/10.1016/j.msec.2017.03.125
23. Nair LV, Nair RV, Shenoy SJ, Thekkuveettil A, Jayasree RS., Blood brain barrier permeable gold nanocluster for targeted brain imaging and therapy: an in vitro and in vivo study., Journal of Materials Chemistry B., 2017, 5(42):8314-21., https://doi.org/10.1039/C7TB02247F
24. Payanam RU, Shenoy SJ, Arumugham S., Improved Pig Model to Evaluate Heart Valve Thrombosis., The Journal of heart valve disease., 2016, Sep;25(5):606., https://pubmed.ncbi.nlm.nih.gov/28238243/
25. Despang F, Bernhardt A, Lode A, Dittrich R, Hanke T, Shenoy SJ, Mani S, John A, Gelinsky M., Synthesis and physicochemical, in vitro and in vivo evaluation of an anisotropic, nanocrystalline hydroxyapatite bisque scaffold with parallel???aligned pores mimicking the microstructure of cortical bone., Journal of Tissue Engineering and Regenerative Medicine., 2015, Dec;9(12):E152-66., https://doi.org/10.1002/term.1729
26. Basu, B; Sabareeswaran, A; Sachin, J Shenoy., Biocompatibility property of 100% strontium-substituted SiO2?Al2O3?P2O5?CaO?CaF2 glass ceramics over 26 weeks implantation in rabbit model: Histology and micro Computed Tomography analysis ., Journal of Biomedical Materials Research Part B: Applied Biomaterials,, 2015, 01-Oct-14, DOI: 10.1002/jbm.b.33270.
27. Saraswathy, A; Nazeer, S S; Nimi, N; Sabareeswaran, A; Sachin, J Shenoy; Jayashree, R S., Synthesis and characterization of dextran stabilized superparamagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis., Carbohydrate Polymers., 2014, 30;101:760-8., DOI:10.1016/j.carbpol.2013.10.015.
28. Sabareeswaran, A; Basu, B; Sachin, J Shenoy; Jaffer Z, Saha, N; Stamboulis, A ., Early osseointegration of strontium containing glass ceramic in a rabbit model., Biomaterials., 2013, 34(37):9278-86., DOI:10.1016/j.biomaterials.2013.08.070
29. Despang F, Bernhardlt A, Lode A, Dittrich R, Hanke T, Sachin, J Shenoy, Mani S, John A and Gelinsky M., Synthesis and physicochemical, in vitro and in vivo evaluation of an anisotropic, nanocrystalline hydroxyapatite bisque scaffold with parallel-aligned pores mimicking the microstructure of cortical bone., Journal of Tissue Engineering And Regenerative Medicine., 2013, , DOI: 10.1002/term.1729.
30. Vidhya L, Sachin, J Shenoy, Umashankar, PR., Feed Induced Chronic Copper Toxicosis In Stall-Fed Sheep., International Journal of Livestock Research, 2012, 2(3): 219-222., www.scopemed.org/?mno=19074
31. Indu, NN; Lekshmi, V;Sachin, J Shenoy; Umashankar, PR., Hypokaleamia with Respiratory Alkalosis in Anaesthetized Goats., Indian Veterinary Journal., 2012, 89(9): 51-52
32. Fernandez, FB; Sachin, Shenoy; Babu, SS; Varma, HK; John, A., Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration., Biomedical Materials., 2012, 7(3):035005., PMID:22406527.
33. Sujesh, S; Rajeev, A; Sachin, J Shenoy; Umashankar, PR;and Muraleedharan, C.V;, An automated data acquisition system for capturing physiological parameters during animal trials of artificial heart valves., Int. J. Biomedical Engineering and Technology,, 2012, 10(1): 70-83., DOI:10.1504/IJBET.2012.049326
34. Kurian, M V;Umasankar, P R; Sabareeswaran, A; Sachin, J Shenoy; Subban, V; Joseph, M K., A new concept in the sewing rings for mechanical heart valves., Asian Cardiovasc Thorac Ann., 2012, 20 (4): 409-417., DOI: 10.1177/0218492312438741
35. Beena, G Mohan; Sachin, J Shenoy;Suresh, Babu S; Varma, HK; John, A. ., Strontium calcium phosphate for the repair of leporine (Oryctolagus cuniculus) ulna segmental defect., Journal of Biomedical Mater Res Part A, 2012, 101A : 261-271, DOI: 10.1002/jbm.a.34324
36. Kaur, S; Harikrishnan, VS; Sachin, J Shenoy; Radhakrishnan, NS;Uruno, A;Sugawara, A; Kartha, CC., Transfection of Endothelial Nitric Oxide Synthase Gene Improves Angiogenic Efficacy of Endothelial Progenitor Cells in Rabbits with Hindlimb Ischemia., Journal of Clinical & Experimental Cardiology, 2011, 2-140, DOI:10.4172/2155-9880.1000140
37. Ganesh,.G;Sachin, J. Shenoy;.Umashankar, P.R, Long Duration Anaesthetic Regimen for Major Surgical Procedures in Goats., Indian Veterinary Journal, 2011, 88(5) : 20-21.
38. Nair, MB; Varma, HK; Menon, KV; Sachin, J Shenoy; John, A., Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma., Acta Biomaterialia, 2009, 5:1742-1755., DOI:10.1016/j.actbio.2009.01.009
39. Nair, MB; Varma, HK; Menon, KV;Sachin, J Shenoy; John, A., Tissue regeneration and repair of goat segmental femur defect with bioactive triphasic ceramic-coated hydroxyapatite., Journal of Biomedical Materials Research Part A., 2009, 91(3):855-65., DOI:10.1002/jbm.a.32239
40. Harikrishnan, VS; Sachin, J Shenoy;Umashankar, PR, Anesthetic Regimen for Coronary Stenting in Porcine Model., The Indian Veterinary Journal, 2006, 83(5):486-489
41. Sachin, J Shenoy;Umashankar PR;Lal GAV, Management of Damaged Lumbosacral Plexus Due to Foetopelvic Disproportion in a Gilt., Indian Veterinary Journal, 2006, 83(11): 1204-1205
42. Ravishankar, C; Muthuramalingam, M; Sachin, J Shenoy; Mini M; Jayaprakasan, V., Isolation of Streptococcus suis from a fatal case of Pneumonitis in a Boar., The Indian Veterinary Journal, 2005, 82(8): 910-911, http://agris.fao.org/agris-search/search.do?recordID=IN2006001627