Mr. Muraleedharan C. V.

Academic Qualifications

• M. Tech (Control Systems and Instrumentation); Regional Engineering College, Calicut (currently NITC), INDIA (1987).
• B. Tech (Electrical Engineering); Regional Engineering College, Calicut (Currently NITC), INDIA (1983).

Professional Record

• Lecturer; Regional Engineering College (currently NITC), Calicut, India; (Mar 1985 - Oct 1985).
• Scientist / Engineer; Biomedical Technology Wing, SCTIMST, Trivandrum, India; (Nov 1985 - continuing).

Honors

• Certified Laboratory Assessor, National Accreditation Board for Testing and Calibration Laboratories (NABL), Government of India.
• Approved signatory for Calibration, National Accreditation Board for Testing and Calibration Laboratories, Government of India.

Awards

• VI Mantra 2008 from National Instruments , Bangalore, 2008.
• Meritorious Invention Award from National Research and Development Corporation (NRDC), New Delhi, 2007.
• ISTE-L&T Award from Indian Society for Technical Education, New Delhi -1997.
• FIE Foundation Award from FIE Foundation, Kolhapur, 1995.
• Republic Day Award from National Research Development Corporation (NRDC), New Delhi, 1994.
• Incentive Award for Technology Development from SCTIMST, 1991.
• National Technlogy Award, DIPT, GoI, 2014

Area of Interest

• Medical devices, Biomaterials .
• Information management .
• Quality systems, calibration and metrology .

Collaboration

• Babha Atomic Research Centre, Mumbai
• National Aeronautical Laboratories, Bangalore
• CNRS, Paris, France
• Central Electrochemical Research Institute, TN

Current Activities

• Product development of coronary stent systems, Deep Brain Stimulator, Implantable Cardioverter Defibrillator.
• GLP in medical devices, Reference materials, Calibration.
• Medical device retrieval analysis.
• Coordinator, Technical Research Centre for Biomedical Devices

पेटेंट

• Muraleedharan CV, Sumesh S, Pranha D nair, A bioreactor system incorporating perfusion and hydro-pneumatic stimulation for articular cartilage tissue engineering, Indian Patent Application, 2010.
• Mohanan PV, Sidharh B, Muraleedharan CV, An in vitro pyrogen test kit using human blood, Indian Patent Application, 2010.
• Muraleedharan CV , Sujesh S, A metallic stent for use as support in blood vessels, Indian Patent Application, Dec 2008.
• Sujesh S, Muraleedharan CV, A stent for use in blood vessels, Design Registration Application, Dec 2008.
• Roy Joseph, Manju S, Rajeev A, Jayakrishnan A, Muraleedharan CV, Vascular graft sealed with biodegradable hydrogel, Indian Patent Application, Dec 2008.
• Roy Joseph, Anumon VD, Muraleedharan CV, Curcumin containing coating compositions for treating coronary restenosis, Indian Patent Application, Jul 2008.
• Roy Joseph, Muraleedharan CV, Polyester based implant materials with reduced thrombogenicity and a process for making the same, Indian Patent Application 1972/CHE/2006.
• Nagesh DS, Muraleedharan CV, Bhuvaneshwar GS, Venous Reservoir with integral cardiotomy reservoir for blood oxygenator , Indian Patent Application, 203/MAS2000.
• Nagesh DS, Muraleedharan CV, Bhuvaneshwar GS, A blood oxygenator, Indian Patent Application, 1153/MAS/1999.
• Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, A method of producing heart valve, US patent No.5,458,286, 1995.
• Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, Improvements relating to prosthetic cardiac valve and to the method of manufacturing same, European patent No. 93303377, 1993 .
• Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, Improvements relating to prosthetic cardiac valve and to the method of manufacturing same, Indian patent no. 180653,1992.
• Bhuvaneshwar GS, Muraleedharan CV, An epidural sensor for use in intracranial pressure monitoring system, Indian patent application No.751/MAS/91, 1991.
• Muraleedharan CV, Bhuvaneshwar GS, Improved humidifier for air, oxygen or other gases, Indian patent No. 180294, 1992.
• Rout D, Bhuvaneshwar GS, Pal SN, Muraleedharan CV, Muralitharan M, A shunt device for draining cerebrospinal fluid, Indian patent No. 180185, 1991.

Membership

• Institution of Electrical and Electronic Engineers Inc (IEEE).
• Material Research Society of India (MRSI).
• System Society of India (SSI).
• Society for Polymer Science, India (SPSI).
• Society for Biomaterials and Artificial Organs, India (SBAOI).

On-going Projects

• Development of Improved Tilting Disc Heart Valve Prosthesis .
• Development of Coronary Stent Systems Development of Drug Eluting Intra Uterine Contraceptive Device .
• Development of Coated Vascular Grafts .
• Development of Bioreactors for Tissue Engineering Applications - 3 projects for liver, cartilage and vascular tissue engineering .
• Development of Decellularised Animal Tissue for Cardiovascular Applications .
• Development of guidelines for implementation of GLP in medical device segment in India.
• Medical device retrieval program

Team

• Sujesh S, Engineer F.
• Ranjith G, Enginer E.
• Sajithlal MK, Engineer E.
• Rajeev A, Technical Asst.
• manog

Presentations

Invited talks

No. of Publications

Technology Transferred

• Coated vasvcular graft
• Improved heart valve
• Vascular graft
• Membrane oxygenatoir
• Patient Humidifier
• Tilting disc heart Valve
• Hydrocephalus Shunt System

प्रकाशन

Article

1. Mohanan, PV; Muraleedharan, CV; Bhuvaneshwar, GS; Derangere, F.; Sampeur, Y.; Suryanarayanan, R., Evaluation of maximization sensitization of the saline extract of titanium coated with diamond like carbon material, Toxicology International, 2010, 14; 63, http://www.toxicologyinternational.com/article.asp?issn=0971-6580;year=2007;volume=14;issue=1;spage=63;epage=65;aulast=Mohanan;type=0
2. Joseph, R.; Shelma, R.; Rajeev, A.; Muraleedharan, CV, Characterization of surface modified polyester fabric, Journal of Materials Science: Materials in Medicine, 2009, 20; 153-159, http://www.springerlink.com/content/m577m7253k2w0564/
3. Joseph, Leena; Velayudhan, Arumugham; Charuvila, Muraleedharan V; Vayalappil, Muraleedharan C, Reference biomaterials for biological evaluation., J Mater Sci Mater Med, 2009, 20 Suppl 1; S9-17, http://www.ncbi.nlm.nih.gov/pubmed/18648911
4. Prasad, C Krishna; Muraleedharan, C V; Krishnan, Lissy K, Bio-mimetic composite matrix that promotes endothelial cell growth for modification of biomaterial surface., J Biomed Mater Res A, 2007, 80; 644-54, http://www.ncbi.nlm.nih.gov/pubmed/17051537
5. Anilkumar, TV; Shelma, R.; Joseph, R.; Mohanan, PV; Muraleedharan, CV, Implant pathology of polyvinylidene fluoride coated polyethylene terephthalate fabric in rabbits, Indian Journal of Veterinary Pathology, 2007, 31; 11-16, http://www.indianjournals.com/ijor.aspx?target=ijor:ijvp&volume=31&issue=1&article=002&type=fulltext
6. Muraleedharan, CV; Bhuvaneshwar, GS, Titanium Alloys in implant applications, Metals Materials and Processes, 2006, 18; 441
7. Nair, K.; Muraleedharan, CV; Bhuvaneshwar, GS, Developments in mechanical heart valve prosthesis, Sadhana, 2003, 28; 575-587, http://www.springerlink.com/content/4741263g682j0886/
8. Kumari, T V; Anil Kumar, P R; Muraleedharan, C V; Bhuvaneshwar, G S; Sampeur, Y; Derangere, F; Suryanarayanan, R, In vitro cytocompatibility studies of Diamond Like Carbon coatings on titanium., Biomed Mater Eng, 2002, 12; 329-38, http://www.ncbi.nlm.nih.gov/pubmed/12652027
9. Mohanty, M; Anilkumar, T V; Mohanan, P V; Muraleedharan, C V; Bhuvaneshwar, G S; Derangere, F; Sampeur, Y; Suryanarayanan, R, Long term tissue response to titanium coated with diamond like carbon., Biomol Eng, 2002, 19; 125-8, http://www.ncbi.nlm.nih.gov/pubmed/12202172
10. Krishnan, LK; Varghese, N.; Muraleedharan, CV; Bhuvaneshwar, GS; Derangere, F.; Sampeur, Y.; Suryanarayanan, R., Quantitation of platelet adhesion to Ti and DLC-coated Ti in vitro using 125I-labeled platelets, Biomolecular engineering, 2002, 19; 251-253, http://dx.doi.org/10.1016/S1389-0344(02)00029-1
11. Hussain, MA; Murali, CV; Willi, P.; Sharma, CP; Bhuvneshwar, GS; Sreekumar, R., Comparative complement activation study of polypropylene hollow fibres of two different makes in static condition, Journal of biomaterials applications, 1998, 12; 300-320, http://cat.inist.fr/?aModele=afficheN&cpsidt=2260735
12. Bhuvaneshwar, G S; Muraleedharan, C V; Vijayan, G A; Kumar, R S; Valiathan, M S, Development of the Chitra tilting disc heart valve prosthesis., J Heart Valve Dis, 1996, 5; 448-58, http://www.ncbi.nlm.nih.gov/pubmed/8858513
13. Muraleedharan, CV; Bhuvaneshwar, GS; Valiathan, MS, Materials for Chitra Heart Valve Prosthesis-A Review, METALS MATERIALS AND PROCESSES, 1995, 7; 147-157
14. Chanda, J; Rao, S B; Mohanty, M; Muraleedharan, C V; Arthur, V L; Bhuvaneshwar, G S; Valiathan, M S, Use of glutaraldehyde-gentamicin-treated bovine pericardium as a wound dressing., Biomaterials, 1994, 15; 68-70, http://www.ncbi.nlm.nih.gov/pubmed/8161662
15. Chanda, J; Rao, S B; Mohanty, M; Lal, A V; Muraleedharan, C V; Bhuvaneshwar, G S; Valiathan, M S, Prevention of calcification of tissue valves., Artif Organs, 1994, 18; 752-7, http://www.ncbi.nlm.nih.gov/pubmed/7832657
16. Bhuvaneshwar, GS; Muraleedharan, CV; Ramani, AV; Valiathan, MS, Evaluation of materials for artificial heart valves, Bulletin of Materials Science, 1991, 14; 1363-1374, http://www.springerlink.com/content/1566327386120247/