Dr. R. S. Jayasree

Academic Qualifications

• Post Doctoral Fellowship, Monash University, Melbourne , Australia
• PhD , University of Kerala Trivandrum
• MSc, Cochin University of Science & Technology,Cochin
• BSc, University of Kerala Trivandrum

Professional Record

• Scientist G and Scientist -in-Charge, Division of Biophotonics and Imaging, SCTIMST, 2021-till date
• Scientist-F and Scientist -in-Charge, Division of Biophotonics and Imaging, SCTIMST, 2017-2021
• Scientist - E and Scientist -in-Charge, Division of Biophotonics and Imaging, SCTIMST Trivandrum , 2014-217
• Scientist - D and Scientist -in-Charge, Division of Biophotonics and Imaging, SCTIMST Trivandrum , 2010-2014
• Scientist - C, SCTIMST Trivandrum , 2006-2010
• RA/SO/JSO/PI, SCTIMST Trivandrum , 1996 - 2006
• JRF, SCTIMST Trivandrum , 1987 - 1989

Honors

• DBT Task force on Nanotechnology- Special Invitee, 2017 & 2018
• Member, Selection Committee on SERB International Research Experience (SIRE)
• Member, SERB-VORTEX (Vision ORiented Thought Exchange) program of Inorganic and Physical Chemistry, 2021
• Member, expert committee of SUPRA scheme of SERB, DST, GOI, 2019, 2020
• Member(Co-opted), Program Advisory Committee, Inorganic & Physical Chemistry, SERB, DST,GOI, 2021-till date
• Member, Technical Review and Advisory Committees (TRAC) of the NNetRA project of Ministry of Electronics & Information Technology, GOI, 2016-till date
• Member, Expert Committee on Intensification of Research in High Priority Areas (IRHPA) in the area 3D bioprinting, SERB,DST,GOI, 2020-2022
• Member, Nano Science Advisory Group of Nanomission of DST, GOI, 2018-till date
• Member, Task Force on Empowerment and Equity Opportunities for Excellence in Science, SERB, DST, GOI, 2019 & 2020
• Member, SERB-TETRA AWARD selection Committee, SERB,DST,GOI , 2021 & 2022
• Organizing Secretary-International Symposium on Photonics Applications and Nanomaterials (ISPAN-2015) in October 2015, at Trivandrum, India
• Member, Board of Studies of Physics, Mar Ivanios College, Thiruvananthapuram
• Member-Board of studies of Future Sciences, University of Kerala
• Member, Board of Studies of Nanosciences, University of Kerala
• Member, Board of Studies of Molecular Medicine and Nanotechnology, Amrita Institute of Medical Sciences, Kochi
• Member, human ethics committee of Regional Cancer Centre, Trivandrum
• Represented twice in the GORDON conferences
• Represented India during the 3rd meeting of the BRICS Working group on Material Science and Nanotechnology,2021
• Secretary, Material Research Society of India-Trivandrum (2015-2017)
• President, Material Research Society of India, Thiruvananthapuram(2021- 2023)
• Treasurer, Society for Biomaterials & Artificial Organs (India)
• Assistant Editor, Asian Journal of Physics (2016-till date)
• Australia Award Ambassador (Nominated by Australian High Commissioner , 2014-2017
• Guest Editor, Special issue of Materials Today Proceedings (Elsevier), 2017
• Endeavor Research Fellowship By Australian Government, 2010
• DBT Task force on Nanotechnology- Special Invitee, 2017
• Organizing Secretary-International Symposium on Photonics Applications and Nanomaterials (ISPAN-2015) in October 2015, at Trivandrum, India
• Certificate of Good Clinical Practice from NIDA Clinical Trial Networks, 2020
• PhD Examiner of several Universities
• Nodal Officer of SCTIMST for the Gender Advancement for Transforming Institutions (GATI) scheme initiated by DST, GOI
• Fellow of Royal Society of Chemistry
• Member-Board of studies of BMT & CE, SCTIMST
• Australian Awards Ambassador 2012-2016
• Secretary of MRSI, Trivandrum chapter 2015-'17.
• Fellow of Academy of Sciences, Chennai

Awards

• Best Woman Scientist Award 2023, ISAS
• Listed as the Women in Nanoscience by Royal Society of Chemistry in 2023
• Shreeratna Award -2022 by Kerala Kalakendram, an affiliate of Kerala Sangeeta Nataka Academy, Government of Kerala
• MRSI Award 2017
• Women Scientist Award by Department of Science and Technology, 2005
• Endeavour Research Fellowship by Australian Government, 2009
• PSN National Award for Excellent R & D in rural technology in 2011

Area of Interest

• Optical neural modulation and optogenetics
• Application of Lasers in Medicine.
• MR imaging
• Optical imaging
• Nanobiophotonics
• Biophotonics
• Biomedical application of Fluorescence, Raman and IR spectroscopy, Spectral Mapping

Collaboration

• Department of Physics, CUSAT, Kochi
• Department of Optoelectronics, University of Kerala
• University of Pau, France
• NIT, Calicut
• Cochin University of Science and Technology, Kochi
• University of Bangalore , Bengaluru
• IIST, Thiruvananthapuram
• IIT Madras- combined PhD Program
• CSIR-CLRI, Chennai
• University of Pau,France
• RMIT University, Melbourne
• Govt. Dental College & PMS Dental College, Thiruvananthapuram University of Kerala
• Toyo University, Japan
• RIKEN,Japan
• CSIR-NIIST,Thiruvanandapuram
• IISER, Thiruvananthapuram
• RGCB, Thiruvananthapuram

Current Activities

• Biosensors and IVDs: Nanosensors and Lateral Flow Assay kits for neuro and cardiac markers
• Nanosystems to cross Blood brain barrier for imaging and therapy of neurodegenerative diseases
• Application of lasers in medicine : Diagnostic and therapeutic Approaches-Fluorescence , Raman and Infrared spectroscopy and spectral mapping for diagnosis (Optical pathology)
• Development of Photodynamic and Photothermal Therapy probes, Optical Molecular and cellular Imaging - treatment, follow up and imaging, Image processing
• Development of optical and MRI imaging probes/contrast agents
• In vivo and ex vivo Fluorescence and Raman Spectroscopic and Imaging techniques for oral cavity disorders, brain tumour and cardiovascular disease
• Biomaterials-Metallic, semiconducting and polymeric nanomaterials for imaging and therapy: Optical imaging, MR Imaging, CT imaging
• Biophotonics based device development for medical applications

पेटेंट

• Multi functional fluorescent nanosensor for simultaneous detection of copper and creatinine and the process there of
• Gold quantum cluster for targeted brain imaging and delivery of foreign molecules (drugs, nutrients, therapeutics etc.) through blood brain barrier
• An ultrasensitive nanosensor for dopamine detection and the process thereof, (Application No.IPBPI204/Y20) A filter system for circulating tumor cells
• Design and fabrication of filter prototype for circulating tumor cells (Indian Design Application -Granted)
• Preparation of iron oxide nanoparticles with high transverse relaxivity and saturationMagnetization for imaging applications-Granted
• Method of preparation of urease and gold Quantum cluster mediated nanobiosensor for the detection of blood urea and the process involved-Granted
• Detection and removal of endosulfan from ground water using Cadmium Selenium quantum dots-Jayasree RS and Lakshmi.V.Nair

Fellowships

• Hon. Fellow of Indian Society of Analytical Scientists
• Fellow of the Royal Society of Chemistry
• Endeavour Research Fellowship by Australian Government, 2009
• Feloow of Academy of Sciences, Chennai

Membership

• Optical society of india - Life Member
• Photonics society of india - Life Member
• Indian laser association - Life Member
• International Society for Magnetic Resonance in Medicine - Associate member
• Society for Biomaterials and Artificial organs - Life Member
• Society for Tissue Engineering and Regenerative Medicine - Life Member
• Material Research Society of India-Life Member

On-going Projects

• Blood brain barrier targeted Nanoconstructs for the diagnosis of brain diseases and the delivery of therapeutics into the brain, DBT project (PI)
• Magneto-Optic Sensor for Cardiac Biomarker detection (PI), DST India-Japan Cooperative Science Program(IJCSP)
• An easy and Rapid detection platform for viral diseases from saliva: COVID-19 and beyond(PI)
• Development of nanosensors for the blood based biomarkers for Alzheimer's disease
• An ultrasensitive sensor platform for the circulating tumor cells (PI)
• Design and development of nanosensor based Lateral flow assay kit for the detection of COVID-19,SERB project (PI)

Projects Completed

• Detection of Zinc in Epileptic Condition using Ratiometric Fluorescent Molecular Probes.Principal Investigator : Dr. Jayasree.R.S Multi Institutional Project in collaboration with NIIST, Trivandrum. Funding agency Department of Biotechnology Govt.of India.
• Functional Gold Nanorods for Targeted Photodynamic Therapy and Diagnostic Fluorescence Imaging. Principal Investigator : Dr. Jayasree.R.S Funding agency Indian Council of Medical Research Govt.of India
• Development of nanosensors for simultaneous sensing of multiple analytes
• Gold nanorod based targeted nanoprobe for cancer theranostics: Diagnosis by Surface Enhanced Raman Scattering (SERS) and Fluorescence imaging and therapy by PDT and PTT: Multi-Institutional Project between SCTIMST and CSIR-NIIST (Institute PI)(Funded by DBT)
• Development of iron oxide nanoprobe for asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis
• Blood brain barrier targeted Nanoconstructs for the diagnosis of brain diseases and the delivery of therapeutics into the brain, Principal Investigator : Dr.R.S. Jayasree, Funding Agency-Department of Biotechnology, Government of India
• Raman and fluorescence spectroscopic protocol for the diagnosis of viral diseases(in Shrimp) and blood vessel abnormalities(in humans)
• Nanohybrids for chemodynamic/Photothermal /Photodynamic therapy/Hyperthermia Fluorescence Spectroscopic protocol for the early diagnosis of oral cavity disorders, breast cancer and brain tumors.
• Quantum dot conjugated single walled carbon nanotubes for imaging and therapy (Indo-Japan project Funded by DST) (Indian PI)
• Graphene-Gold Nanohybrid-Based SERS Platform for Liquid Biopsy Detection of Circulating Breast cancer cells
• Development of Iron Nanoparticles for Magnetic resonance angiography (PI) (Funded by SCTIMST)
• Development of iron oxide nanoprobes for organ specific molecular MR imaging(PI)(Funded by BRNS)
• Autofluorescence spectroscopy and multivariate analysis for diagnosis liver tumor and also for predicting the induced damages to other organs
• Development of Optical Nerve Stimulator (PI)
• Magnetic Resonance Spectroscopic techniques for the temporal lobe epilepsy of rabbit model.

Team

• Jijo.P.T, Technical Assistant
• Dhujana.N.S, PhD student
• Anjana R S, PhD student
• Dhushyandhun, PhD student
• Sarathkumar E, PhD student
• Resmi A N-PhD student

Presentations

• Presentation at the Gordon Research Conference on Medicine and Biology- ‘Unmet Needs and New Directions in Translational Biophotonics’ July 8-13, 2018 Bates College Lewiston, ME, USA
• ‘Spiky Gold nanostar decorated Graphene hybrid nanoprobe: A multifunctional Cancer Theranostics’ during the World Biomaterials Conference (WBC 2020) during December 11-17, 2020

Invited talks

• Plenary speaker at “Global Congress & Expo on Biomaterials (Biomaterials-2019)” held during May 13-14, 2019 at Kuala Lumpur, Malaysia.
• Tuning the properties of nanoconstructs for Biosensing, Biomedical Imaging and Therapy’ at Nano Medical Engineering Laboratory, RIKEN, Japan on 25th February 2020
• ‘Biosensing & Organ Specific Biomedical Imaging and Therapy-Nanotechnological approach’ at Institute for Frontier Life and Medical Sciences , Kyoto University, Japan on 14th February 2020
• Nanotechnology for Biosensing & Organ Specific Biomedical Imaging and Therapy’ at Nano Medical Engineering Laboratory, RIKEN, Japan on 25th February 2020
• Keynote Lecture on ‘Gold nanostructures-A potential candidate for Biomedical Imaging, Therapy and Sensing’ at International Conference on Nanoscience and Photonics for Medical Applications (ICNPMA-2019) during December 28-30, 2019 at MAHE, Manipal
• Keynote lecture on Pre clinical evaluation of the L-dopa functionalized fluorescent gold nanocluster for targeted brain imaging at International Conference on Translational Medicine and Imaging (ICTMI-17), 28-29 August, 2019 at VIT University, Vellore
• Functionally Engineered Nanostructures for imaging, sensing and therapy at the 8th East Asia Symposium(EAS8) on Functional Dyes and Advanced Materials held at CSIR-NIIST, 20 - 22 September 2017
• Targeted Imaging of Brain and Drug Delivery Across Blood Brain Barrier: A Nanotechnological Approach at the International Workshop on Recent Materials for Healthcare & Industrial Applications IWRM 2018 Organized by Anna University, Chennai, January 22 – 23, 2018
• ‘Advances in Bio-Nanosensors: Current Scenario and Future Prospects’ during International Conference on Spectroscopy of Biomolecules and Advanced Materials Christian College, Chengannur, Kerala, India during Oct 4-7, 2017
• “Recent trends in Nanosensors and their applications in medicine and biology” during International Conference on Material Science and Technology, October 10-13, 2018, Thiruvanathapuram
• Role of photonics and Magnetic nanomaterials in diagnostic and therapeutic applications during 6th Asia Biomaterials Congress, October 25-27, 2017
• ‘Nanotechnology:a platform for brain imaging and drug delivery’ during the International Brain Research Organization(IBRO) Asia Pacific Regional Committee school 2019 held during 22 April to 6 May, 2019
• ‘Organ specific biomedical Imaging and Therapy: Recent advances’ during International conference on Biomaterial-based Therapeutic Engineering and Regenerative Medicine(BioTERM 2019), held at IIT Kanpur, 28Nov-1 Dec, 2019
• Comprehensive understanding of the breast cancer therapeutic efficiency of vanadium nanospheres: An electron microscopic story” delivered during International conference on Optoelectronic and nano materials for Advanced Technology held during January 2-5, 2019 at CUSAT,Kochi
• ‘Functionally Engineered gold nanocluster For Sensing, Imaging and Therapeutic Applications’ on 2nd July, 2018- at North Eastern University, Boston
• Tuning optical and magnetic properties of metallic nanoparticles for biomedical application 7th East Asia Symposium on Functional Dyes and Advanced Materials, Osaka, Japan, 2nd to 5th September, 2015
• Multimodal in vivo detection of liver fibrosis using asialoglycoprotein receptor mediated targeting of ironoxide nanoparticles 4th Nano Today Conference, Dubai, UAE, 5th to 10th December, 2015
• Metallic and Semiconducting Nanoconstructs for Bioimaging and therapy,Indo-Australian Conference on Biomaterials Tissue Engineering, Drug delivery system and Regenerative medicine, February 5-8, 2015, Anna University Chennai
• Enhanced diagnostic potential of MR and optical imaging using metallic nano carriers. Indo-UK Workshop on Medical Technologies, Chennai, 11-03-2014
• Nanocarriers for sensing, Imaging and Therapy, Indo-German conference on Laser Applications and Nanoscience, Mascot Hotel, Trivandrum, December 5-7, 2013
• Nanotechnology for Bioimaging and Biosensing, Nano Bio Collaborative International Conference 2013 at Bharathidasan Institute of Technology, Anna University, Tiruchirappalli, June 27-29, 2013
• Raman spectral analysis of human coronary bypass grafts, ICORS 2012 - 23rd International Conference on Raman Spectroscopy , Bangalore, India, August 12-17, 2012
• NIR Emitting Gold NanoconstructFor Brain Imaging, Second International Conference on Medical Materials, Devices and Regenerative Medicine, Kathmandu, Nepal, January 11-13, 2014
• Vibrational spectral analysis of human coronary bypass grafts, 5th International Conference on Perspectives in Vibrational Spectroscopy, Trivandrum,08-12 July 2014
• Poster on “Diagnostic potential of tissue hemoglobin concentration and oxygen saturation using fluorescence spectroscopy for the demarcation of brain tumor” at the Gordon conference on Lasers in Medicine and Biology at Holderness, Plymouth, MA, USA during 22nd to 27thJuly, 2012
• “Raman spectral analysis of human coronary bypass grafts” at the International Conference on Raman Spectroscopy during 12th to 17th August in IISC, Bangalore, 2013

No. of Publications

• More than 100

Dissertations Supervised - Ph.D

• Development of highly fluorescent nanosystems for biomedical sensing, imaging and therapeutic applications-Resmi.V.Nair
• Nano-bio interactions: Cellular and molecular effects of nanoscale vanadium pentoxide on mammalian and microbial models-Parvathy.R.S
• Nanotechnology: Novel fluorescent nanoconstructs for early diagnosis, therapy and sensing-Lakshmi.V.Nair
• Design, fabrication and evaluation of graphene-gold nanohybrids for sensing, imaging and therapeutic applications-Jibin.K
• Fluorescence spectroscopic diagnosis of malignancy associated changes in brain, oral cavity and liver-Shaiju.S.Nazeer
• Design and fabrication of fluorescent probes for biomedical applications: potential tool for in vitro and in vivo bioimaging, sensing and SiRNA delivery for cancer therapy-Hema Santhakumar
• Development of nanoprobes for Optical and Magnetic Resonance Molecular Imaging-Ariya Saraswathy
• Advanced Magnetic Resonance Imaging Techniques for the Differentiation and Characterization of Brain Tumors with Histopathology Correlation-Smitha.K.A
• Integrating technologies to create modular sensors for water quality monitoring-Vidhya.S (SCTIMST-IIT Madras-CMC Vellore combined program)

Select Publications

• L.V. Nair, S.S.Nazeer, R.S. Jayasree, A. Ajayaghosh, Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer Linked Gold Quantum Clusters, ACS Nano, 9, 5825–5832, 2015
• N Nimi, A Saraswathy, S.S Nazeer, N. Francis, S.J Shenoy, R.S Jayasree, Multifunctional hybrid nanoconstruct of zerovalent iron and carbon dots for Magnetic Resonance Angiography and Optical Imaging: An In vivo study, Biomaterials, ,171, 46-56, 2018
• L. V. Nair , Y. Nagaoka , T. Maekawa , D. Sakthikumar, R.S. Jayasree. Quantum Dot Tailored to Single Wall Carbon Nanotubes: A Multifunctional Hybrid Nanoconstruct for Cellular Imaging and Targeted Photothermal Therapy, Small, 10, 2771–2775, 2014. (Cover Page)
• Ariya Saraswathy, Shaiju S Nazeer, N Nimi, S Arumugam, SJ Shenoy, R.S. Jayasree, Synthesis and characterization of dextran stabilized super paramagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis. CarbohydrPolym, 101, 760– 768. 2014
• Parvathy Radhakrishna Pillai Suma, Renjini A Padmanabhan, Srinivasa Reddy Telukutla, Rishith Ravindran, Anoop Kumar G Velikkakath, Chaitali D Dekiwadia, Willi Paul, Malini Laloraya, Srinivasa M Srinivasula, Sheshanath V Bhosale, Ramapurath S Jayasree, Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis, Free Radical Biology and Medicine, 161, 198-211,2020
• Nair LV, Philips DS,Jayasree R.S, Ajayaghosh A. A near-infrared fluorescent nanosensor (AuC@Urease) for the selective detection of blood urea. Small., 9, 2673-7, 2013.
• Kunnumpurathu Jibin, Ramesh Babu V, and R.S. Jayasree, Graphene–Gold Nanohybrid-Based Surface-Enhanced Raman Scattering Platform on a Portable Easy-to-Use Centrifugal Prototype for Liquid Biopsy Detection of Circulating Breast Cancer Cells, ACS Sustainable Chem. Eng. 9, 46, 15496–15505, 2021

Reviewer

• International Journal of Biological Macromolecules, Elsevier
• Luminescence: The Journal of Biological and Chemical Luminescence, Wiley
• Journal of Physics and Chemistry of Solids, Elsevier
• Physical Chemistry Chemical Physics, RSC
• Langmuir, ACS
• RSC Advances, RSC
• Biomaterials Science, RSC
• Advanced functional Materials, Wiley
• Optical Engineering, SPIE
• Photobiomodulation, Photomedicine, and Laser Surgery
• Journal of Biophotonics, WIley
• Biotechnology and Bioengineering, Wiley
• Journal of Material Chemistr B, RSC
• ACS Applied materials and Interfaces, Americal Society of Chemistry
• Chemical Society Reviews, Royal Society of Chemistry
• Advanced Health Materials, Wiley

प्रकाशन

Article

1. Hema Santhakumar, Resmi V. Nair, Divya Maldepalli Govindachar, Ganga Periyasamy and Ramapurath S. Jayasree, Engineering of Tripeptide-Stabilized Gold Nanoclusters with Inherent Photosensitizing Property for Bioimaging and Photodynamic Therapy,, ACS Sustainable Chem. Eng. 2023, 11, 6, 2102–2114, 2023,
2. AN Resmi, CR Rekha, ME Dhushyandhun, S Elangovan, SJ Shenoy,KK Gulia, RS Jayasree, Bifunctional cysteine gold nanoclusters for β-amyloid fibril inhibition and fluorescence imaging: a distinctive approach to manage Alzheimer's disease, , Journal of Materials Chemistry B, 2023, 11, 4715-4724, 2023,
3. Resmi V Nair, Muhammed Fasil Puthiyaparambath, Raghu Chatanathodi, Lakshmi V Nair, Ramapurath S Jayasree, A nanoarchitecture of a gold cluster conjugated gold nanorod hybrid system and its application in fluorescence imaging and plasmonic photothermal therapy, , Nanoscale, 2022, 14, 13561-13569, 2022,
4. Lakshmi V. Nair, Shaiju S. Nazeer, Ramapurath S. Jayasree, and Ayyappanpillai Ajayaghosh., Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer-Linked Gold Quantum Clusters., ACS Nano, 2015, 9(6), http://pubs.acs.org/doi/abs/10.1021
5. BS Kumar, S Sandhyamani, SS Nazeer, RS Jayasree, Rapid and simple method of photobleaching to reduce background autofluorescence in lung tissue sections, IJBB, 2015, 52, http://www.ncbi.nlm.nih.gov/pubmed/26040118
6. E.B. Ansar, Shaiju. S.Nazeer,F.Francis, M.Krishna Surendra,W. Wilfried, S.Anil, V.Sajith, M.S.Rao, J. Annie, R.S.Jayasree, HK.Varma, An aqueous method for the controlled manganese (Mn2+)substitution in superparamagnetic iron oxide nanoparticle for contrast enhancement in MRI, Phys. Chem. Chem. Phys, 2015, 17, http://pubs.rsc.org/en/content/articlehtml/2014/cp/c4cp05122j
7. Nazeer SS, Sandhyamani S, Jayasree RS, Optical diagnosis of the progression and reversal of CCl(4)-induced liver injury in rodent model using minimally invasive autofluorescence spectroscopy, Analyst, 2015, 140(11), http://www.ncbi.nlm.nih.gov/pubmed/25853289