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Dr. Rekha M.R.

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Contact Information

Address:

Dr. Rekha M.R.
Scientist 'G'
बायोफोटोनिक्स और इमेजिंग प्रभाग

Phone number:

1214(O), 2432850 (R)

People - Division of Biosurface Technology

Dr. Rekha M.R.

Academic Qualifications

  • Ph.D Biochemistry, University of Kerala, 2001.
  • M.Phil Biochemistry, University of Kerala, 1996.
  • M.Sc Biochemistry, University of Kerala, 1994.
  • B.Sc Chemistry, University of Kerala, 1992.

Professional Record

  • Scientist F (2017 - till date)
  • Scientist E (2014 - 2017)
  • Scientist- D (2011- 2014)
  • Scientist -C (2007-2011, SCTIMST).
  • Research Associate (2002-2007, SCTIMST).
  • Research Associate (1996-2001, CTCRI).

Awards

  • Received WBC 2016 - Developing Country Scholarship Award at 10th World Biomaterials Congress held at Montreal, Canada during May 17-22, 2016

Area of Interest

  • Nanomedicine, Nanotechnology based drug and gene delivery systems, oral peptide delivery systems.

Current Activities

  • Non-viral gene delivery systems, nano polymeric gene and drug delivery systems, drug delivery systems and pH probes for wound dressings

पेटेंट

  • pH sensitive nanoparticle formulation for oral delivery of proteins/peptides, patent granted (EP 1924248 B1 dated 22/10/2014, CA 2621641 dated 21/10/2014) Inventors: Chandra P Sharma and Rekha M.R.
  • Method for In-Vivo Binding of Chromatin Fragments. PCT filed. US Patent publication no. 20150218262 (06/08/2015). Inventors: Indraneel Mittra, Rekha M.R, C.P. Sharma, G.S. Bhuvaneshwar, Kavita Pal

Fellowships

  • GATE 1995 - 98.51 percentile
  • UGC Junior Research Fellowship -1995-1996

Membership

  • MRSI
  • SBAOI
  • STERMI
  • SPSI
  • ISRC

Projects Completed

  • Oral Insulin Delivery System ( 2017 to 2020)
  • Chitosan based antioxidant wound dressing for controlled antibiotic delivery (2017 to 2019)
  • Indo-Spanish (under DST) project - "Development of nanodevices for DNA delivery and cell transfection using Elastin Like Polymers (ELPs) coupled to cell interaction motifs" (Co-PI) (October 2010 to Septmber 2013)
  • DBT project - Nonviral gene delivery vectors for therapeutic gene and siRNA delivery for glioma targeting: In vitro evaluation of cationized pullulan based materials. (April 2012 to August 2015)

No. of Publications

  • 6 Book Chapters
  • 66 publications in International Peer Reviewed Journals

Dissertations Supervised - Ph.D

  • Synthesis and evaluation of multifunctional nanothiomatrices for an efficient antitumour therapy, done by Ms. Priya S.S
  • Non-viral gene delivery in cancer cells using polysaccharides modified with polyethyleneimine and vinyl monomers, done by Ms. Caroline Diana Sherly

Dissertations Supervised - M.Phil

  • POLYETHYLENEIMINE BASED NON-VIRAL VECTORS FOR p53 GENE DELIVERY IN CANCER CELLS, done by Linsha Mali A.
  • FORMULATION AND EVALUATION OF MUCOADHESIVE CHITOSAN MICROPARTICLES FOR ORAL INSULIN DELIVERY: AN IN-VITRO STUDY, done by Hanna Karneena Poulose
  • PHYSICO CHEMICAL CHARACTERIZATION OF CHITOSAN BASED SCAFFOLD AS WOUND HEALING BIOMATERIAL, done by Divya M.R.

Select Publications

  • Caroline D.S. and Rekha M.R. Exploring the efficacy of ethylene glycol dimethacrylate crosslinked cationised pullulan for gene delivery in cancer cell. Journal of Drug Delivery Science and Technology, 68, 2022, 2022, 103067, https://doi.org/10.1016/j.jddst.2021.103067 (IF: 5.062)
  • G P Rajalekshmy, M R Rekha, Wound healing effects of glucose oxidase – peroxidase incorporated alginate diamine PEG-g-poly (PEGMA) xerogels under high glucose conditions: An in vitro evaluation. Materialia, 23, 2022, 101464, https://doi.org/10.1016/j.mtla.2022.101464. (Cite score 4.7)
  • Priya S.S. and Rekha M.R. Intracellular delivery of p53 gene and drug using cationised pullulan thiomer lowers the effective therapeutic doses of chemotherapeutic drug in cancer cells. Materials Today Communications. https://doi.org/10.1016/j.mtcomm.2022.103129 (IF: 3.662)
  • Linsha Mali, A., Priya, S. S., Rekha, M. R., Hydrophobic and hydrophilic modifications of polyethylenimine towards gene delivery applications. Journal of Applied Polymer Science, 2021, 138( 45), e51323. https://doi.org/10.1002/app.51323 (IF: 3.057)
  • GP Rajalekshmy, MR Rekha. Synthesis and evaluation of an alginate-methacrylate xerogel for insulin delivery towards wound healing applications. Therapeutic Delivery, 12, 2021, 215-234. https://doi.org/10.4155/tde-2020-0128 (IF: 2.448)
  • Rajalekshmy GP, Rekha MR, Strontium ion cross-linked alginate-g-poly (PEGMA) xerogels for wound healing applications: in vitro studies, Carbohydrate Polymers, 251, 2021, 117119 (IF: 10.723)
  • Caroline Diana Sherly, Rekha M.R and Harikrishnan V.S. Cationised dextran and pullulan modified with diethyl aminoethyl methacrylate for gene delivery in cancer cell Carbohydrate Polymers, 242, 2020, 116426 (IF: 9.381)
  • Dhanya G.R., Caroline Diana Sherly and Rekha M.R. Histidine and arginine conjugated starch-PEI and its corresponding gold nanoparticles for gene delivery. International Journal of Biological Macromolecules, 120, 2018, 999-1008. (IF: 4.787)
  • Priya S.S and Rekha M.R. Redox sensitive cationic pullulan for efficient gene transfection and drug retention in C6 glioma cells. International Journal of Pharmaceutics, 530, 2017, 401-414. (IF:3.862)
  • Caroline DS and Rekha M.R. Efficacy of vinyl imidazole grafted cationized pullulan and dextran as gene delivery vectors: A comparative study. International Journal of Biological Macromolecules, 105, 2017, 947-955. (IF:3.909)

Reviewer

  • Reviewer for International Journals in the field of Biomaterial Science and Drug/gene delivery, Wound healing

प्रकाशन

Article

  1. Rekha MR and Sharma C.P., Simultaneous effect of thiolation and carboxylation of chitosan particles towards mucoadhesive oral insulin delivery applications: an in vitro and in vivo evaluation, Journal of Biomedical Nanotechnology, 2015, 11, 165-176, http://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000001/art00014
  2. Lizebona A.A and Rekha M.R, Betaine conjugated cationic pullulan as effective gene carrier., International Journal of Biological Macromolecules, 2015, 72, 819-826, http://www.sciencedirect.com/science/article/pii/S014181301400645X
  3. Maria J. Piña, Susan M. Alex, Francisco J. Arias, Mercedes Santos, Jose C. Rodriguez-Cabello, Rekha M.R. and Chandra P. Sharma, Elastin-like recombinamers with acquired functionalities for gene-delivery applications, Journal of Biomedical Materials Research Part A, 2015, 103, 3166-3178, http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35455/full
  4. Soma Dey, Lizebona August Ambattu, PR Hari, MR Rekha, K Sreenivasan, Glutathione-bearing fluorescent polymer-curcumin conjugate enables simultaneous drug delivery and label-free cellular imaging, Polymer, 2015, 75, 25-33, http://www.sciencedirect.com/science/article/pii/S0032386115301592
  5. Lizebona A.A and Rekha M.R, Collagen synthesis promoting Pullulan-PEI-Ascorbic acid conjugate as an efficient anti-cancer gene delivery vector, Carbohydrate Polymers, 2015, 126, 52-61, http://www.sciencedirect.com/science/article/pii/S014486171500226X
  6. Rekha M.R and Sharma C.P., Recent advances in the oral delivery of insulin, Recent Patents on Drug Delivery & Formulation, 2014, 8, 155-159, http://www.ingentaconnect.com/content/ben/ddf/2014/00000008/00000002/art00007
  7. Priya S.S, Rekha M.R and Sharma C.P, Pullulan-protamine as efficient haemocompatible gene delivery vector: Synthesis and in vitro characterization, Carbohydrate Polymers, 2014, 102, 207-215, http://www.sciencedirect.com/science/article/pii/S0144861713011648
  8. Mitha Ann Thampy and Rekha M.R, Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and Mitoxantrone, Journal of Materials Chemistry B, 2014, 2, 8005-8014, http://pubs.rsc.org/en/content/articlehtml/2014/tb/c4tb01298d
  9. M.R. Rekha and Sharma C.P, Oral delivery of therapeutic protein/peptide for diabetes-Future perspectives., International Journal of Pharmaceutics, 2013, 440, 48-62, http://www.sciencedirect.com/science/article/pii/S0378517312003249
  10. Thasneem Y.M., Rekha M.R., Sajeesh S., and Sharma C.P, Biomimetic mucin modified PLGA nanoparticles for enhanced blood compatibility., Journal of Colloid and Interface Science, 2013, 409, 237-244, http://www.sciencedirect.com/science/article/pii/S0021979713006449
  11. M.R. Rekha Pal, K., Bala, P., Shetty, M., Mittra, I., Bhuvaneshwar, G.S., and Sharma C.P, Pullulan-histone antibody nanoconjugates for the removal of chromatin fragments from systemic circulation, Biomaterials, 2013, 34, 6328-6338, http://www.sciencedirect.com/science/article/pii/S0142961213005735
  12. Jane Joy Thomas, M. R. Rekha, and Chandra P., Sharma Unraveling the Intracellular Efficacy of Dextran-Histidine Polycation as an Efficient Nonviral Gene Delivery System., Molecular Pharmaceutics, 2012, 9, 121-134, http://pubs.acs.org/doi/abs/10.1021/mp200485b
  13. Rekha M.R and Sharma C.P, Polymers for gene delivery: Current status and future perspectives., Recent Patents on DNA and Gene Sequences, 2012, 6, 98-107, http://www.ingentaconnect.com/content/ben/dnag/2012/00000006/00000002/art00004
  14. Durga Das C.V., Sharma C.P., Paul W., Rekha M.R. and Sreenivasan, K, Aggregation of gold nanoparticles followed by methotrexate release enables Raman imaging of drug delivery into cancer cells., Journal of Nanoparticle Research, 2012, 14, 1-12, link.springer.com/article/10.1007/s11051-012-1127-7
  15. Rajesh R, Rekha M.R and Sharma C.P., Evaluation of lauryl chitosan graft polyethyleneimine as a potential carrier of genes and anticancer drugs, Process Biochemistry, 2012, 47, 1079-1088, http://www.sciencedirect.com/science/article/pii/S1359511312001171
  16. M.R. Rekha and Sharma C.P, Modification of chitosan nanoparticles for improved gene delivery, Nanomedicine, 2012, 7, 5-8, http://www.futuremedicine.com/doi/abs/10.2217/nnm.11.170
  17. Rekha M.R. and Sharma C.P, Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency, Acta Biomaterialia, 2011, 7, 370-379, http://www.sciencedirect.com/science/article/pii/S1742706110003478
  18. Susan M. Alex, Rekha M.R and Chandra P Sharma, Spermine grafted galactosylated chitosan for improved nanoparticle mediated gene delivery, International Journal of Pharmaceutics, 2011, 410, 125-137, http://www.sciencedirect.com/science/article/pii/S0378517311002043
  19. Rekha M.R and Chandra P. Sharma, Intracellular trafficking mechanism and cytosolic protein interactions of a non viral gene delivery vector: Studies based on transferrin conjugated Pullulan-PEI ., Current Nanoscience, 2011, 7, 879-885, http://www.ingentaconnect.com/content/ben/cnano/2011/00000007/00000006/art00009
  20. Sonia, TA; Rekha, MR; Sharma, C.P., Bioadhesive hydrophobic chitosan microparticles for oral delivery of insulin: In vitro characterization and in vivo uptake studies, Journal of Applied Polymer Science, 2011,
  21. Thomas J.J., Rekha M.R. and Chandra P Sharma, Dextran-glycidyltrimethylammonium chloride conjugate/DNA nanoplex: A potential non-viral and haemocompatible gene delivery system, International Journal of Pharmaceutics, 2010, 389, 195-206, http://www.sciencedirect.com/science/article/pii/S037851731000044X
  22. Thomas J.J., Rekha M.R. and Chandra P. Sharma, Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery, Colloids and Surfaces B: Biointerfaces., 2010, 81, 195-205, http://www.sciencedirect.com/science/article/pii/S0927776510003796
  23. Rekha M.R and Sharma C.P, Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption, Journal of Controlled Release, 2009, 135, 141-151, http://www.sciencedirect.com/science/article/pii/S0168365909000479
  24. Rekha M.R and Chandra P Sharma, Challenges and Advances in Nanoparticle Based Oral Insulin Delivery., Expert Review in Medical Devices, 2009, 6, 665-676, http://www.tandfonline.com/doi/abs/10.1586/erd.09.43#.VfFVTH1GTgw
  25. Rekha M.R., C.P. Sharma, Blood compatibility and in vitro transfection studies on cationically modified pullulan for liver cell targeted gene delivery, Biomaterials, 2009, 30, 6655-6664, http://www.sciencedirect.com/science/article/pii/S0142961209008564
  26. Rekha M.R and Sharma C.P, Succinyl chitosan nanoparticles: A preliminary investigation towards oral insulin delivery applications, Trends in Biomaterials and Artificial Organs, 2008, 21, 107-115, http://medind.nic.in/taa/t08/i2/taat08i2p107.pdf
  27. Rekha M. R., C. P. Sharma, Phthalyl chitosan-poly(ethylene oxide) semi-interpenetrating polymer network microparticles for oral protein delivery: An in vitro characterization., Journal of Applied Polymer Science, 2008, 110, 2787-2795, http://onlinelibrary.wiley.com/doi/10.1002/app.28832/full
  28. Rekha MR and Sharma C.P, Pullulan as a promising biomaterial for biomedical applications: A Perspective., Trends in Biomaterials and Artificial Organs, 2007, 20, 116-121, http://www.biomedsearch.com/article/Pullulan-as-promising-biomaterial-biomedical/165363930.html