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Dr. Umashankar P. R.

1527 UMASHANKAR

Contact Information

Address:

Dr. Umashankar P. R.
Scientist 'G' & Scientist-in-Charge
इन विवो मॉडल और परीक्षण प्रभाग

Phone number:

1226(O), 2351241 (R)

People - Division of In Vivo Models and Testing

Dr. Umashankar P. R.

Academic Qualifications

  • PhD in Regenerative Medicine, (2011- Division of Implant Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, India).
  • Master of Veterinary Science. In Veterinary Pathology, (2001- Department of Pathology, College of Veterinary and Animal Sciences , Mannuthy, Trichur, India
  • Bachelor of Veterinary science and Animal Husbandry, (1994- College of Veterinary and Animal Sciences , Mannuthy, Trichur, India

Professional Record

  • Scientist F (Veterinary), SCTIMST, Thiruvananthapuram, 2012 continuing
  • Scientist E (Veterinary), SCTIMST, Thiruvananthapuram, 2008- 2012
  • Scientist D (Veterinary), SCTIMST, Thiruvananthapuram,2004 -2008
  • Veterinary Scientist C , SCTIMST, Thiruvananthapuram, 2000 -2004
  • Veterinary Surgeon, SCTIMST, -1995 to 2000 April
  • Veterinary Surgeon, Department of Animal Husbandry, Kerala. 1994.

Awards

  • Appreciation award from Department of Animal Husbandry, Government of Kerala (2007), for transfer of technology 'A filed kit for testing antibiotic sensitivity for veterinary application'.

Area of Interest

  • Medical device translational studies such as "Proof of concept" and Preclinical evaluation of medical devices in animal models.
  • Development of decellularised/ heparin cross-linked processed animal tissue for cardiovascular application.

Current Activities

  • Preclinical evaluation of biodegradable drug eluting coronary stent and non-invasive coronary blood flow monitor in porcine coronary artery model. drug eluting coronary stents for Industry.
  • Development of decellularised/ non-calcifying glutaraldehyde cross-linked / heparin cross-linked animal tissue such bovine/ buffalo pericardium, jugular vein, and saphenous vein for cardiovascular application.

पेटेंट

  • Indian patent, granted Title: A field kit for testing antibiotic sensitivity of mastitic milk Application number: 942/MAS/2001 date 21-11-2001
  • Indian patent, under examination Title: A process for non-detergent based decellularisation of animal tissue for therapeutic human implantation' Application no. 2113/CHE/2008 dated 29-08-08
  • PCT patent Title: Biocompatible and biodegradable biopolymer matrix Application no: PCT/IN2008/000818 Publication date: 11-06-2009.
  • US patent Title: Biocompatible and biodegradable biopolymer matrix Application no: 12/746,625, date 8th Dec 2008. Publication no: 2010/0260845 A1
  • European patent Application EP2231134 Title: Biocompatible and biodegradable biopolymer matrix Application no: EP20080857894 dated 12-08-2008 Publication date: 29-9-2010
  • Indian patent applied Title: Single step method for covalently linking heparin to decellularised tissue. Application no. 4529/CHE/2012 dated 30-10-2012
  • Indian patent applied Title: Processed bovine pericardial valved conduit and method of its fabrication. Application no. 4044/CHE/2015, 4th August 2015

Membership

  • Indian Veterinary Association
  • Indian Society for Veterinary Surgery
  • Indian Association for Veterinary Pathology
  • Society for Biomaterials and Artificial Organs, India
  • Society for Tissue Engineering and Regenerative Medicine, India
  • Material Research Society of India

On-going Projects

  • Application of decellularised bovine pericardium for fabrication of a novel valved conduit for RVOT reconstruction in sheep model

Team

  • Dr. Sachin J Shenoy,Scientist D (Veterinary)
  • Dr. Dayamon D Mathew, CHVF (Veterinary)
  • Smt. Smitha P, Technical Assistant (Anesthesia)
  • Sri. Prem Mohan, Technical Assistant (Lab)
  • Sri. Manoj Kumar, Animal care taker
  • Sri. Biju V, Animal care taker

प्रकाशन

Article

  1. Umashankar PR, Sabareeswaran A and Sachin J Shenoy., Long term healing of mildly crosslinked decellularised bovine pericardial aortic patch, JBMR-Part B, 2016, DOI:10.1002/jbm.b.33755
  2. P Suvaneeth, NN Divakaran, PR Umashankar, N Narayanan, MJ Abraham, C Divya and Martin J, In vitro characterization of differently processed decellularised bovine pericardium, LJ Livestock Science, 2015, 7:13-18
  3. Harikrishnan VS and Umashankar PR., Cerebral protection for the preclinical evaluation of a vascular graft in sheep carotid artery model, Scandinavian Journal of laboratory Animal Sciences , 2015, 41(3):1-8.
  4. Parvathy Thampi, Divakaran Nair, Lalithakunjamma R, Vijayan N, Syam Venugopal and Umashankar Ramachandra, Pathological Effects of Processed Bovine Pericardial Scaffolds—A Comparative In Vivo Evaluation, Artificial Organs , 2013, 37(7):600-605
  5. Umashankar P.R, Arun T and Kumari.T.V, Effect of chronic Inflammation and immune response on regeneration induced by decellularised bovine pericardium., J Biomed Mater Res Part A , 2013, 101A: 2202-2209
  6. Lekshmi Vidhya, Sachin J Shenoy and Umashankar P.R., Feed induced chronic copper toxicosis in stall fed sheep., Int. J. Livest. Res , 2012, 2(3):219-222
  7. Sujesh S, Rajeev A, Shenoy Sachin J, PR Umashankar, Muraleedharan CV, International Journal of Biomedical Engineering and Technology, International Journal of Biomedical Engineering and Technology, 2012, 10(1-10):70-83.
  8. Indu N.N. ‘Observation of Hypokalaemia in conjunction with respiratory Aakalosis in Anaesthetised Goats’Sachin Shenoy.J , Lekshmi.V, Umashankar P.R., Observation of hypokalemia in conjunction with respiratory alkalosis in anesthetised goats., Indian Veterinary Journal, 2012, 89(9):51-53
  9. Mathew V Kurian, Payanam R Umasankar, Arumugam Sabareeswaran, Sachin J Shenoy, Vijayakumar Subban and Mathew K Joseph, A new concept in the sewing rings for mechanical heart valves., Asian Cardiovasc Thorac Ann, 2012, 20:409-417
  10. P.R. Umashankar, Mohanan PV and Kumari TV., Glutaraldehyde treatment elicits toxic response compared to decellularisation in bovine pericardium, Toxicology International, 2012, 19(1):51-58.
  11. P.R. Umashankar, Arun T and Kumari T.V., Short duration glutaraldehyde crosslinking of decellularised bovine pericardium improves biological response, . J Biomed Mater Res A. , 2011, 97(3): 311-320
  12. Ganesh G, Sachin J Shenoy and Umashankar P.R., Long duration anaesthetic regimen for major surgical procedure in goats., Indian Veterinary Journal, 2011, ; 88(5): 20-21
  13. Huang Y, Venkatraman SS, Boey FY, Lahti EM, Umashankar PR, Mohanty M, Arumugam Sabareeswaran, Khanolkar L, Vaishnav S, In vitro and in vivo performance of a dual drug-eluting stent (DDES), Biomaterials, 2010, 31(15):4382-91, http://www.sciencedirect.com/science/article/pii/S014296121000195X
  14. Yingyning, Subbu S Venkatraman, Freddy YC Boey, P.R. Umashankar, Mira Mohanty and Sabareeswaran A., The short term effect on restenosis and thrombosis of a Co-Cr stent eluting two drugs in porcine coronary artery model, J. Interven. Cardiol, 2009, 22(5):466-478.
  15. Umashankar,P.R, P.R. Hari and K. Sreenivasan, Effect of blood flow on drug release from DES: an experimental study, International Journal of Cardiology, 2009, 131(3):415-7
  16. Balram Barghava, Ganeshan Kartikeyan, P.R. Bheema Shankar, Sandeep Seth, Sandeep Singh, Umashankar.P.R, A.V. lal and Mira Mohanty, Preclinical and early clinical experience with a biodegradable polymer based Rapamycin Eluting Indian drug eluting coronary stent: BIO-RAPID Study, Indian Heart Journal, 2008, 60(3):228-232
  17. Leena Kuruvilla, R.Renuka Nair, P R Umashankar, A V Lal, C C Kartha, Endocardial endothelial cells stimulate proliferation and collagen synthesis of cardiac fibroblasts, Cell Biochem Biophys, 2007, 47: 65-72, DOI:10.1385/CBB:47:1:65
  18. Harikrishnan, V.S and P.R. Umashankar, Long duration anaesthesia for experimental surgical procedures in pigs, Indian Veterinary Journal, 2006, 1173-1175
  19. S. N. J. Shenoy, P. R. Umashankar, G. A. V. Lal, Management of damaged lumbosacral plexus due to foetopelvic disproportion in a gilt, Indian Veterinary Journal, 2006, 83(11):72-73
  20. Harikrishanan, V.S, Sachin J Shenoy,and P.R. Umashankar, Anesthetic regimen for coronary stenting in porcine model., Indian Veterinary Journal, 2006, 83:486-489
  21. L. Kuruvilla, R. R. Nair, A. V. Lal, P. R. Umashankar, C. C. Kartha, TNF-alpha depresses endocardial endothelial cell mediated proliferation of cardiac fibroblasts., Journal of Molecular and Cellular Cardiology, 2005, 38(5):840-840. 
  22. Biji Balakrishnan, Mohanty M, Umashankar PR, Jayakrishnan A, Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin, Biomaterials, 2005, 32: 6335-42.
  23. LK Lissy, Mira Mohanty, P.R. Umashankar, Arthur Vijayan Lal, Comparative evaluation of absorbable hemostats: advantages of fibrin based sheets, Biomaterials, 2004, 25(24): 5557-63
  24. LK Krishnan, Mira Mohanty, PR Umashankar, Arthur Vijayan Lal., Fibrinolysis inhibitors adversely affect remodeling of tissue sealed with fibrin glue., Biomaterials, 2003, 24(2):321-327
  25. S. Abhiram, H.K. Varma, T.V. Kumari, Umashankar and Annie John., Preliminary in vitro and in-vivo characterization of a sol-gel derived bioactive glass-ceramic system., Bull. Mater. Sci. , 2002, 1.    25(5):419-429.
  26. S. Abhiram, H.K. Varma, Umashankar and Annie John., Fibrin glue as an osteoinductive protein in a mouse model., Biomaterials, 2002, 23:3023-3031
  27. Vasudev S.C.; Chandy T, Mohanty M, Umashankar,.P.R, Sharma C.P, Inhibition of Bioprosthesis Calcification Due to Synergistic Effect of Fe/Mg Ions to Polyethylene Glycol Grafted Bovine Pericardium, Journal of Biomaterials Applications, 2001, 16(2):93-107
  28. Umashankar, P.R, Mira Mohanty and N, Divakaran Nair, AgNOR staining technique for studying peri-implant fibroblast proliferation, Indian Journal of Veterinary Pathology, 2001, 25(1&2): 81-82
  29. S. Rajasree, Umashankar PR, A.V. Lal, P Sankara Sarma and C.C. Kartha., 1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D, Life Sciences , 2000, 70:1777-1788
  30. C Maya Devi, Mary Vasantha Bai, A.V. Lal, Umashankar PR and Lissy,K.K, An improved method for isolation of anti-viper venom antibodies from chicken egg yolk, Biochemical and biophysical methods, 2000, 51:129-138
  31. Annie John,S Abiraman, H K Varma, T V Kumari and P R Umashankar, Bone growth response with porous Hydroxyapatite granules in a critical sized lapine tibial defect model, Bull. Mater. Sci. , 2000, 25(2):
  32. Umashankar P.R, Lal Arthur Vijayan, Krishnan Lissy K and Mohanty Mira, Evaluation of fibrin glue for neuro-surgical application in a rabbit model, Indian Journal of Veterinary Surgery, 2000, 21(2)
  33. Umashankar P.R, Lal Arthur Vijayan and Mohanty Mira, Biocompatibility evaluation of silicone scleral buckling device, Indian Journal of Veterinary Surgery, 2000, 21(2).
  34. Sindu, C. Vasudev; Thomas Chandy; Chandra. P. Sharma; Mira Mohanty and P.R. Umashankar, Synergestic effect of released Aspirin/Heparin for bovine pericardial calcification, Artificial Organs, 2000, 24(2):
  35. Sindu, C. Vasudev; Thomas Chandy; Chandra. P. Sharma; Mira Mohanty and P.R. Umashankar, Effects of double cross-linking technique on the enzymatic degradation and calcification of bovine pericardia, J. Biomaterials applications , 2000, 14:273-295
  36. P.R. Umashankar and Arthur Vijayan Lal, Cerebral Angiography in dogs: An experimental study, Indian J. Vet. Surg , 1999, 20(1): 25-27.
  37. P.R. Umashankar and Arthur Vijayan Lal, A method for blood pressure measurement in conscious restrained rabbit, Indian Vet. J, 1998, 75: 738-739.
  38. Ashokan,K.K; Umashankar,P.R; Lal,G.A.V; and Rathinam,K, Observation of Proteus mirabilis from rabbit conjunctivitis and it's relation to Vitamin A deficiency, Indian Vet. J. , 1997, 74:471-473
  39. Santhosh Kumar, T.R; Umashankar,P.R; and Arthur Vijayan Lal:, Effect of oxygen supplementation under xylazine-ketamine anethesia in adult rats, Trends in biomatarials and Artificial organs, 1996, 10(1&2):44-48
  40. Umashankar,P.R; Santhosh Kumar,T.R; and Arthur Vijayan Lal, Modified Xylazine-Ketamine injectable anaesthesia by atropine sulphate-Diazepam premedication in Rabbits for bone implatation, Trends in biomatarials and Artificial organs, 1996, 10(1&2).27-36