Dr. Rajalakshmi P.

Academic Qualifications

• PDF- Neuropathology, NIMHANS, Bangalore, 2015
• MD- Pathology, Mysore medical College and Research Institute, RGUHS, Karnataka, 2011
• MBBS, JIPMER,Pondicherry university, 2005

Professional Record

• Associate Professor, SCTIMST, Trivandrum, August 2019 till date
• Assistant Professor, SCTIMST, Trivandrum, August 2016 to August 2019
• Senior Resident, NIMHANS, Bangalore, January 2016 to June 2016
• Junior Consultant, Bangalore Hospital, Bangalore, August 2015 to December 2015
• PDF- Neuropathology, NIMHANS, Bangalore, July 2014 to June 2015
• Senior Resident, JIPMER, Puducherry, March 2013 to June 2014
• Assistant Professor, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, July 2011 to March 2013

Awards

• NPSICON 2019 Glioblastoma with primitive neuronal component: a clinicopathological study Case discussion 3rd prize
• International travel grant from SERB for attending ICN 2018, Japan
• ILAE scholarship for attending INES 2016, Erlangen, Germany
• SACH 2016 Cerebral amyloid angiopathy presenting as intracerebral hematoma- a histopathological audit 2nd prize
• NPSICON 2015 Neuropathological spectrum of Drug Resistant Epilepsy over a decade @ NIMHANS Best poster award
• CYTOCON 2013 A malignant adnexal tumor of the vulva-a pathological diagnostic dilemma between primary cutaneous mucinous carcinoma and malignant chondroid syringoma Third best poster prize

Area of Interest

• Neuropathology, Epilepsy Pathology

Fellowships

• Post-Doctoral Fellowship- Neuropathology

Membership

• Neuropathology Society of India
• Indian Association of Pathology and Microbiology

On-going Projects

• Extramural funded projects: DNA methylation profiling of Gangliogliomas and Dysembryoplastic Neuroepithelial Tumors Funding agency: SERB, DST

अनुसंधान

• Extramural funded projects: DNA methylation profiling of Gangliogliomas and Dysembryoplastic Neuroepithelial Tumors Funding agency: SERB, DST
• Intramural projects: Non-neoplastic and non-infective cysts of the central nervous system: a histopathological study
• Intramural projects: Endolympahtic sac tumor: a histopathologic case series
• Intramural projects: Gliosis and destructive brain lesions associated with drug resistant epilepsy- a clinicopathological and radiological study

Presentations

• E Poster presentation: Clinical and radiological features of antibody positive neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at ICN 2023 12th-16 Sept 2023, Berlin, Germany
• AOCN-NPSICON 2021 Gliotic and destructive brain lesions associated with drug resistant epilepsy- a clinicopathological study
• NPSICON 2019 Glioblastoma with primitive neuronal component: a clinicopathological study
• ICN 2018 Classification systems in surgical pathology of drug resistant epilepsy: the old versus new
• ICN 2018 Multifocal central nervous system demyelination in a 40 year old: is it paraneoplastic?
• NPSICON 2017 Vascular changes in dural biopsies of Moyamoya disease
• SACH 2016 Cerebral amyloid angiopathy presenting as intracerebral hematoma- a histopathological audit
• NPSICON 2015 Neuropathological spectrum of Drug Resistant Epilepsy over a decade @ NIMHANS
• APCON 2015 Neuropathological spectrum of drug resistant epilepsy over a decade ??? an audit from a tertiary care centre
• CYTOCON 2013 A malignant adnexal tumor of the vulva-a pathological diagnostic dilemma between primary cutaneous mucinous carcinoma and malignant chondroid syringoma
• JIPMER Scientific Society meeting 2006 A community based epidemiological study of incidence and prevalence of strokes in Pondicherry town ??? Burden of stroke in three different populations

Invited talks

• Embryonal tumors in Chitra Neuropathology Update, Trivandrum 07.10.2023
• Case based discussion on adult-type diffuse gliomas in Chitra Neuropathology Update, Trivandrum 07.10.2023
• Non–neoplastic Epilepsy associated pathologies NSI/NPSI collaborative educational program Virtual course in Neuropathology 19th august 2023
• Molecular updates in gliomas and meningioma in Trivandrum Neurosurgical Forum 25.03.2023
• Focal Cortical Dysplasia at 6th Annual National Conference of the Neuropathology Society of India (NPSICON 2023) 24th to 25th February 2023
• A Post-Graduate teaching session on Cardiovascular Pathology for MD Pathology students at Department of Pathology, Government Medical College, Trivandrum
• Brain autopsy technique webinar conducted by SMVMCH, Puducherry 27.01.2021
• New Observations on Moyamoya Disease at Cardio-Vascular Pathology Update 2018 11.03.2018 & 12.03.2018, SCTIMST, Trivandrum
• Cerebral Amyloid Angiopathy at Cardio-Vascular Pathology Update 2018 11.03.2018 & 12.03.2018, SCTIMST, Trivandrum

No. of Publications

• Mondal S, Sivadasanpillai H, Poyuran R. Olfactory schwannoma with hypertrophic cardiomyopathy: incidental association? Acta Cardiol. 2023 Sep 12:1-2. doi: 10.1080/00015385.2023.2256184.
• Pavuluri H, Kv V, Thomas B, Vilanilam GC, Nair P, Narasimhaiah DA, Poyuran R, Menon RN. Clinical Reasoning: A Teenager With Chronic Meningitis-Does Occam's Razor Apply? Neurology. 2023 Apr 25;100(17):828-835. doi: 10.1212/WNL.0000000000206783. Epub 2023 Feb 6. PMID: 36746637; PMCID: PMC10136020.
• Narasimhaiah D, Nair P, Kesavadas C, Poyuran R. Rapid malignant transformation of an intracranial epidermoid cyst: Report of a case. Neuropathology. 2022 Dec 4. doi: 10.1111/neup.12884. Epub ahead of print. PMID: 36464491.
• Poyuran R, Kalaparti VSVG, Thomas B, Kesavapisharady K, Narasimhaiah D. Nonneoplastic and noninfective cysts of the central nervous system: A histopathological study. Neuropathology. 2022 Oct 10.
• Deepti N, Chandran K, Venkat EH, Rajalakshmi P. Primary leiomyosarcoma of dura mater with loss of ATRX protein expression. Pathol Int. 2022 Sep;72(9):465-468. doi: 10.1111/pin.13259. Epub 2022 Jul 14. PMID: 35833621.
• Lotlikar R, Menon RN, Thomas B, Poyuran R, Narasimhaiah D, Ponnambath DK. MOG-Antibody Mediated Clinically Isolated Syndrome after COVID-19 in a Post Partum Woman- A Veritable 'Double Hit'! Neurol India. 2022 May-Jun;70(3):1281-1282.
• Patel BK, Divakar G, George T, Kesavapisharady K, Rajeev SP, Easwer H V, Poyuran R. Dumbbell chondrosarcoma of lumbar spine with intradural extension: A unique case. J Spinal Surg [serial online] 2022 [cited 2022 Jun 8];9:120-4.
• Poyuran R, Shah SP, Kesavapisharady K, Chandrasekharan K, Narasimhaiah D. Intracranial mesenchymal tumour with EWSR1 gene rearrangement: the first report of intracranial mesenchymal tumour with FET-CREB fusion from India. Pathology. 2022 May 12:S0031-3025(22)00132-5.
• Poyuran R. Pathology of surgically remediable epilepsy: How to evaluate. Indian J Pathol Microbiol. 2022 May;65(Supplement):S176-S188.
• Narasimhaiah D, Thomas B, Abraham M, Poyuran R. Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma-A Diagnostic Dilemma for the Pathologist. J Neurosci Rural Pract. 2021 Jul;12(3):596-598.
• Narasimhaiah D, Sreedharan SE, Anoop A, Radhakrishnan NR, Poyuran R. Myasthenia Gravis with Thymoma and a Rare Serological Profile-Report of a Case and Review of Literature. Neurol India. 2021 Mar-Apr;69(2):528-529.
• Jain K, Cherian A, Divya KP, Poyuran R, Krishna S. Amidst the madness of genetic adult myopathies: a rare, treatable MADD. Neurol Sci. 2021 Oct 29.
• Narasimhaiah D, Sudhir BJ, Poyuran R. Balloons in Filum Terminale Ependymoma. Neurol India. 2021 Jul-Aug;69(4):1123-1124.
• Poyuran R, Chandrasekharan K, Easwer HV, Narasimhaiah D. Glioblastoma with primitive neuronal component: An immunohistochemical study and review of literature. J Clin Neurosci. 2021 Nov;93:130-136.
• Poyuran R, Mahadevan A, Mhatre R, Arimappamagan A, Sinha S, Bharath RD, Rao MB, Saini J, Raghavendra K, Mundlamuri RC, Sadashiva N, Rajeswaran J, Satishchandra P, Chandramouli BA, Shankar SK. Neuropathological spectrum of drug resistant epilepsy: 15-years-experience from a tertiary care centre. J Clin Neurosci. 2021 Sep;91:226-236.
• Chandrasekharan SV, Sundaram S, Malaichamy S, Poyuran R, Nair SS. Myoneuropathic presentation of limb girdle muscular dystrophy R8 with a novel TRIM32 mutation. Neuromuscul Disord. 2021 Sep;31(9):886-890.
• R Poyuran, DK Ponnambath, GC Vilanilam, K Chandrasekharan, Narasimhaiah D. Mycobacterial spindle cell pseudotumour of the brain in an immunocompetent adult. Pathology. 2021 Oct;53(6):782-785.
• Menon S, Saxena S, Rajalakshmi. Open heart surgery in an infant with hereditary spherocytosis and a review of literature. J Card Surg 2021;36(2):720-722.
• Jain K, Cherian A, Divya KP, Rajalakshmi P, Thomas B, Nandana J. FLAMES: A novel burning entity in MOG IgG associated disease. Multiple Sclerosis and Related Disorders 49, 102759
• Alex A, Ayyappan A, Valakkada J, Pillai VV, Sreekantan R, Poyuran R. Pericardial pseudocyst along atrioventricular groove. BJR Case Rep. 2020 Dec 18;7(2):20200122
• Sudhir BJ, Honavalli Murali S, Gohil J, Poyuran R, Sethuraman M, Harihara Venkat E. Cyanosis and Clipping: Noninfectious Aneurysm in a Patient with 22q11.2 Deletion Syndrome. Pediatr Neurosurg. 2021;56(1):45-49.
• Vaidya P, Nair P, Abraham M, Rajalakshmi P. A rare case report of aspergillosis of CNS presenting as a clival mass causing SAH from a mycotic aneurysm in an immunocompetent patient. Neurol India 2020;68:202-3.
• Poyuran R, Dharan BS, Sandhyamani S, Narasimhaiah D. Mucormycosis induced ileocecal perforation: A case report and review of literature. J Postgrad Med 2020;66:48-50.
• Mhatre R, Poyuran R, Arimappamagan A, Sinha S, Kulanthaivelu K, Kenchaiah R, Ajay A, Chowdary RM, Saini J, Bharath RD, Zanzmera P, Seetharam R, Sadashiva N, Jamuna R, Satishchandra P, Malla BR, Sk S, Anita M. Dual/double pathology in neurocysticercosis causing drug resistant epilepsy - Chance association or causal? Epilepsy Res. 2020 Dec;168:106472.
• Bhavya B, Easwer HV, Vilanilam GC, Anand CR, Sreelakshmi K, Urulangodi M, Rajalakshmi P, Neena I, Padmakrishnan CJ, Menon GR, Krishnakumar K, Deepti AN, Gopala S. MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha. Life Sci. 2021;264:118673.
• Narasimhaiah D, Nair P, Poyuran R. Unusual finding in a cerebral cavernous malformation of the temporal lobe. Cardiovasc Pathol 2020;49:107245.
• Poyuran R, Thomas B, Abraham M, Narasimhaiah D. Meningioma with rosettes: A rare morphologic pattern. Neuropathology. 2019 Dec 2.
• Bhavya B, Anand CR, Madhusoodanan UK, Rajalakshmi P, Krishnakumar K, Easwer HV, Deepti AN, Gopala S. To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma. Cell Mol Neurobiol. 2019 Sep 4. doi: 10.1007/s10571-019-00730-3.
• Jaiswal PA, Vilanilam GC, Rajalakshmi P, Kumar KK, Abraham M. Intracranial migrating bone dust: Innocuous or evil? Neurol India. 2019;67(2):534-536. doi: 10.4103/0028-3886.258041.
• Poyuran R, Moudgil N, Arimappamagan A, Bharath RD, MahadevanA. Pigmented variant of pleomorphic xanthoastrocytoma - A rare long-term epilepsy associated neoplasm. Indian J Pathol Microbiol 2019;62:445-7.
• Sekar S, Vinayagamani S, Thomas B, Poyuran R, Kesavadas C. Haemosiderin cap sign in cervical intramedullary schwannoma mimicking ependymoma: how to differentiate? Neuroradiology. 2019;61(8):945-948.
• Vysakha KV, Poyuran R, Nair SS, Nair M. An unusual presentation of scleromyxedema as inflammatory myopathy. Acta Myol. 2019;38(1):13-16. eCollection 2019 Jun.
• Poyuran R, Mahadevan A, Arimappamagan A. et al. Cerebrovascular pathology in cerebral amyloid angiopathy presenting as intracerebral haemorrhage. Virchows Archiv 2019;474:235???245
• Umesh SU, Arun K, Sreedharan SE, Rajalakshmi P, Sylaja PN. Moyamoya disease associated with hereditary spherocytosis. Neurol India. 2018;66(4):1174-1175. doi: 10.4103/0028-3886.237016
• Sadashiva N, Poyuran R, Mahadevan A, Bhat DI, Somanna S, Devi BI. Chordoid meningioma: a clinico-pathological study of an uncommon variant of meningioma. J Neurooncol. 2018 May;137(3):575-582. doi: 10.1007/s11060-018-2748-1.
• Rajalakshmi Poyuran, BH Srinivas and Bhawana A Badhe: Vasculitis causing massive infarction: a rare presentation of primary cerebral phaeohyphomycosis. Tropical Doctor 2018;48(1):40-43.
• Rajalakshmi Poyuran, Nandeesh BN, Yerasi Varun Kumar Reddy and Amey R. Savardekar. Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case. Neuropathology 2017 doi:10.1111/neup.12369
• Sadashiva N, Sharma A, Rajalakshmi P, Mahadevan A, Shukla D, Devi BI, Intracranial Extraskeletal Mesenchymal Chondrosarcoma, World Neurosurgery (2016),
• Rajalakshmi Poyuran, Anita Mahadevan, B K Chandrasekhar Sagar, Jitender Saini, Dwarakanath Srinivas. Chordoid Glioma of Third Ventricle With an Epidermoid Cyst: Coexistence or Common Histogenesis? International Journal of Surgical Pathology 2016, Vol. 24(7) 663???667.
• Sadashiva N, Rajalakshmi P, Mahadevan A, Vazhayil V, Rao KN, Somanna S. Surgical treatment of Langerhans cell histiocytosis of cervical spine: case report and review of literature. Childs Nerv Syst. 2016 Jun;32(6):1149-52.
• Benachinmardi KK, Rajalakshmi P, Veenakumari HB, Bharath RD, Vikas V, Mahadevan A, et al. Successful treatment of primary cerebral mucormycosis: Role of microbiologist. Indian J Med Microbiol 2016;34:550-3.

No. of Books Authored/ Edited

• Book Chapter Rajalakshmi P, Shilpa Rao, Anita Mahadevan. Surgical Pathology of Intractable Epilepsy. In: Sarkar C, Santosh V, Chacko G, Mahadevan A, editors. Essentials of Diagnostic Surgical Neuropathology; 2nd edition. Thieme;2022:277-282.24-11-2023