Dr. S. Harikrishnan

Academic Qualifications

• PH - LEADER (The Public Health Leadership and Implementation Academy) Programme - Emory University, Atlanta, USA - 2014 -15.
• Commonwealth Fellowship in Coronary Interventions, Leeds University,U.K.-2005-6.
• DNB (Cardiology) - National Board, Govt. of India - 1999.
• DM (Cardiology) , SCTIMST - 1998.
• MD (Gen. Medicine), University of Calicut - 1995.
• MBBS , University of Kerala, Medical College, Trivandrum - 1991.

Professional Record

• Sr Professor in Cardiology, SCTIMST since 2023, Head of Department since 2023
• Worked as Consultant in Cardiology, Indira Gandhi Hospital, Maldives on deputation to initiate and develop the cardiology program in that country. 2005 January 1 to Sept 15.
• Commonwealth Fellow in Interventional Cardiology, Leeds General Infirmary, U.K. 2005 - 2006.
• Ten Day teaching Seminar on Cardiovascular Epidemiology and Prevention of the World Heart Federation - Beijing, China - August - September, 2004.
• Additional Professor in Cardiology, SCTIMST since 1/05/2008.
• Associate professor in Cardiology, SCTIMST 1/5/04-30/04/08.
• Assistant professor in Cardiology, SCTIMST 30/4/00-30/4/04.
• Consultant in cardiology, SCTIMST 2/2/1999 - 2/8/1999.
• Resident in Cardiology, SCTIMST 1/1/1996 - 31/12/1998.

Honors

• Dr. KK Datey memorial oration award: Cardiological Society of India
• JP Das Heart Failure Oration award: Indian College of cardiology

Awards

• MS Valiathan award for the "Outstanding Research Investigator Award" by SCTIMST - 2022
• Amrut Mody Unichem Prize (2018): Indian Council of Medical Research(ICMR) for excellence in research in the field of cardiology, Heart Failure
• Society for Heart Failure and Transplantation (SHFT): Excellence in Publication Award (2018)
• "Challenging Case - OCT" award in the Advanced Cardiovascular Therapeutics, Chennai, 2015
• Won the best case award in the National Interventional Council meet of Cardiological Society of India -- Hyderabad, April 26, 2009.

Area of Interest

• Heart Failure.
• Coronary Interventions, Coronary Physiology - FFR.
• Interventional Cardiology -Structural heart disease interventions, Balloon Mitral Valvotomy.
• Cardiovascular disease Epidemiology

Collaboration

• Center for advanced Research and Excellence in Heart Failure of ICMR – One of the ten National Centres established by ICMR, PI and Team Leader, Seven national collaborative projects under this umbrella
• National HF Biobank - First cardiovascular biobank in India. MOUs signed with InStem Bangalore (DBT) and IIT Madras for collaborative research. 2000 bio-samples stored.
• National Heart Failure Registry – Largest Nationwide Registry of Heart Failure – Supported and Funded by ICMR (Budget 2.87 Crores, Project 2018 – 2021) – 10851 patients enrolled., 54 centres across India
• Trivandrum Heart Failure Cohort: First heart failure long term Cohort in India, Supported by ICMR –(2017 -22)– 1205 patients, 7-year follow-up data collected. 5-year data published.

Current Activities

• CLINICAL :(Includes teaching - DM cardiology program - intake of 6 candidates per year and Post-doctoral fellowship program in Interventional cardiology - 2 seats)
• Catheter interventions:Coronary Interventions, Structural heart disease interventions, Valvular heart disease Interventions - mitral valvotomy. Interventional cardiology clinic - Thursdays.
• Center for advanced Research and Excellence in Heart Failure of ICMR – One of the ten National Centres established by ICMR, PI and Team Leader, Seven national collaborative projects under this umbrella
• Heart Failure :Comprehensive heart failure intervention program Heart Failure clinic - every Wednesday.

Patents

• Indian Patent filed – Number - 202141037246 - A device with Artificial Intelligence (AI) interface for predicting dosage of vitamin K antagonists for managing oral anticoagulant drugs.

Fellowships

• Fellow of the Academy of Medical Sciences India (FAMS) 2021
• Fellow of the International Academy of Cardiovascular Sciences (FIACS-Canada)- 2020
• Fellowship of the Royal College of Physicians, London (FRCP) - 2013.
• Visiting scholar to the University of Sydney, Australia (2010)
• Fellowship of the American College of Cardiology, ACC (FACC)- 2009.
• Commonwealth Fellowship in Interventional Cardiology 2004-5

Membership

• Pulmonary Vascular Research Institute, UK
• Cardiological Society of India

On-going Projects

• ICMR NATIONAL CENTER FOR ADVANCED RESEARCH AND EXCELLENCE IN HEART FAILURE - 5 Crores funding for 5 years. (CARE HF) www.heartfailure.co.in
• CARE HF 1 - Heart Failure Biobank of India
• CARE HF 2 - Targeted Next-Generation Sequencing in Indian patients with Hypertrophic Cardiomyopathy
• CARE HF 3 - Development of a point‐of‐care (POC) device for measuring NT pro‐BNP
• CARE HF 4 - National Heart Failure Database
• CARE HF 5 - The Impact of Heart failure on Household Economic Well-Being
• CARE HF 6 - Quality of Life among HF patients and its Correlates
• CARE HF 7 - A factorial randomized trial of structured physical activity training and brief cognitive behavioural therapy for depression and self-management for prevention of repeat hospital admission and death among acute decompensated heart failure patients
• National Heart Failure Registry – Largest Nationwide Registry of Heart Failure – Supported and Funded by ICMR - 2.87 Crores
• Trivandrum Heart Failure Cohort - First heart failure cohort in India, Supported by ICMR. Longest follow-up of 7 years. 5 year follow-up data published.
• Multi-morbidity study: Systems thinking approach to developing an integrated and patient-centred intervention model for multi-morbidity care in primary care settings in India. Funded by MRC, UK. (Clinician Investigator) (MR/T037822/1)
• Development of a device incorporating a new computer algorithm to aid in managing anticoagulant drugs in patients. National Institute of Technology (NIT) Calicut – and SCTIMST – Joint project- Algorithm developed and tested, device under development at NIT Calicut
• Non-invasive measurement and monitoring of pulmonary congestion in emergency rooms. Joint Project with NIT Calicut and SCTIMST. Funding - DST – Department of Science and Technology, Device Development Programme (DDP)

Projects Completed

• ACS - QUIK - Acute coronary Syndrome Quality improvement in Kerala - NHLBI Funded study (Role - PI)
• PROKERALA - Pulmonary Hypertension registry of Kerala - Funded by Cardiological Society of India. - Largest registry of pulmonary hypertension from developing world. (Role - PI)
• MACE Registry - Management of Acute Coronary Event Registry - The national ACS registry pilot study initiated by ICMR - Indian Council for medical Research - ( Role - PI, Nodal center in Kerala).
• MicroRNAs in Essential Hypertension :Understanding the role of SNPs in influencing blood pressure funded by DST ,Govt of India - DST No: SERB/LS-17/2013, In collaboration with Kerala University . (Role Co-PI)
• Comprehensive Heart Failure Intervention Program funded by ICMR - Funded by Indian Council for Medical Research as an adhoc research project..(Role - PI)
• Influence of Genetic Polymorphisms in Warfarin Requirement in a South Indian Population. Initiated patient recruitment in July 2015 - (Role - PI)
• International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) - Funded by National Heart, Lung, and BloodInstitute (NHLBI). Started 2014 - ongoing - (Role - Co-PI)
• A family based Randomized Controlled Trial of cardiovascular risk reduction in individuals with family history of premature coronary heart disease in India.DBT-WELLCOME Trust project - (Role - Co-PI)
• Developing Patient Education Materials Related To Heart Failure.Funded by Center for chronic disease control, CCDC,NEWDELHI, - (Role - PI)
• Economic impact of ACS in household economic well-being. Multinational study, funded by IC Health, New Delhi, World Bank and WHO. - Results published.
• UMPIRE: Use of a Multidrug Pill in Reducing Cardiovascular Events. (Funded by European Commission) Role - Site PI - SCTIMST, Trivandrum. - Results published.).
• MACE Registry -Management of Acute Coronary Event registry - First nationwide registry of acute coronary syndrome in India initiated by ICMR - Role PI - Nodal center in Kerala, SCTIMST.
• Kerala ACS registry - Largest ACS registry in India - Role - Regional co-ordinator in south Kerala, results published. (European Heart Journal 2013). Funding - Cardiological Society of India.
• CSI KERALA CRP - (Cardiac Risk-factor Profile) study - PI, South Kerala arm - Data collection over. Results being analysed. Funding - Cardiological Society of India
• Coronary Artery Disease in the Young - database of 5000 patients, supported by Kerala State Government, KGCSTE, Role - PI of the project, results presented in World Heart federation, World Congress of Cardiology, Melbourne, 2014.
• Does Non -Regression of Pulmonary Hypertension Following Balloon Mitral Valvotomy Correlate with BMPR 2 Mutations? supported by Pulmonary vascular Research Institute, Canterbury, UK.

Professional Experience

• Head of the division of Adult Cardiology and Interventions. 20 year experience in handling all sorts of interventions in coronary, valve and structural heart disease

Desertations Supervised

• DM Cardiology and Post-Doctoral Fellowship in Interventional Cardiology Theses > 15
• PhD - Ongoing (Sarath S Nair) - Transcutaneous electrical transfer system -TETS
• PhD - Dr Reema George- Platelet function in Young coronary artery disease

Research

• See above in Ongoing and completed projects

Organisational Activities

• National President of the Heart Failure Association of India – Since 2019. (www.hfai.co.in) Works in assortation with HFA of ESC and HF society of America.
• Affiliated Member of the National Heart Failure Societies & working groups Committee of the Heart Failure Association of the European Society of Cardiology

Completed Assignments

• See above in completed projects

Team

• Dr G Sanjay (Professor of cardiology) ,SCTIMST
• Dr Jeemon P, Associate professor of Public Health, Achutha Menon Centre for Health Science Studies, SCTIMST
• Dr Madhusoodanan U.K, Assistant Professor (Biochemistry), SCTIMST
• Dr Radhakrishnan R Nair Scientist Rajiv Gandhi Centre for Biotechnology Trivandrum
• Dr Anugya Bhatt, Scientist F, Thrombosis Research Unit, BMT wing, SCTIMST
• Dr Anoop Kumar T Scientist G, Division of Molecular Medicine BMT Wing, SCTIMST
• Dr Manoj G Scientist D Division of Artificial Internal Organs BMT Wing, SCTIMST
• Santhosh Kumar TR Scientist, Rajiv Gandhi Centre for Biotechnology Trivandrum
• Dr Reethu S, Scientist-B, CARE-HF
• Dr Linda Koshy, Scientist-B, CARE-HF
• Lakshmi Kanth L R, Computer Programmer, CARE-HF
• Vineeth C P, Senior Research Fellow
• Kochumoni R, Research Assistant, THFR
• Greeva Philip, Project Technical Officer (Statistics), CAREHF
• Divya Prasad, Project Assistant, CARE-HF
• Madhuma. M, Project Technician, CARE-HF
• Shamla. S, Junior Nurse, CARE-HF

Books and Journals edited

• Consulting Editor - JACC Heart failure (Journal of the American College of Cardiology - HF) - 2022 onwards
• Editor - International Journal of Epidemiology Since 2017
• Founder Editor-in-Chief - PULMONARY CIRCULATION (2011-2013) International Journal of the pulmonary vascular research Institute - PVRI www.pulmonarycirculation.org). Indexed in pubmed.

Presentations

• > 25 presentations in International forums. >200 presentations in national forums.

Invited talks

• > 20 presentations in International forums. >200 presentations in national forums.

No. of Publications

• >125 publications in international peer-reviewed journals . i10 index - 99, h Index - 36, Citations - >39000

No. of Books Authored/ Edited

• Manual of Heart Failure Management : Harikrishnan.S Editor, Jaypee brothers, New Delhi. 2021. Pages 446, 80 chapters, 100 authors. ISBN 978-93-90595-48-8
• Percutaneous Mitral Valvotomy : Harikrishnan.S (ed), Jaypee brothers, New Delhi; First Edition 2012. Pages 443, Second edition 2018 Pages 500.
• A Race against Time: The Challenge of Cardiovascular Disease in Developing Economies. (Second Edition). S Harikrishnan, Stephen Leeder, Mark Huffman, Jeemon P, D Prabhakaran: December 2014. Center for Chronic Disease Control. New Delhi.

Publications

Article

1. Harikrishnan S, Jeemon P, Ganapathi S, Agarwal A, Viswanathan S, Sreedharan M, Vijayaraghavan G, Bahuleyan CG, Biju R, Nair T, Pratapkumar N, Krishnakumar K, Rajalekshmi N, Suresh K, Huffman MD, Five-year mortality and readmission rates in patients with heart failure in India: Results from the Trivandrum heart failure registry, Int J Cardiol, 2021, 326:139-143, https://pubmed.ncbi.nlm.nih.gov/33049297/
2. Harikrishnan S, Sanjay G, Ashishkumar M, Menon J, Rajesh GN, Kumar RK, George Koshy A, Attacheril TV, George R, Punnoose E, Ashraf SM, Arun SR, Cholakkal M, Jeemon P, Pulmonary hypertension registry of Kerala, India (PRO-KERALA) -Clinical characteristics and practice patterns, Int J Cardiol, 2018, 265:212-217, https://pubmed.ncbi.nlm.nih.gov/29885688/
3. Harikrishnan S, Sarma S, Sanjay G, Jeemon P, Krishnan MN, Venugopal K, Mohanan PP, Jeyaseelan L, Thankappan KR, Zachariah G, Prevalence of metabolic syndrome and its risk factors in Kerala, South India: Analysis of a community based cross-sectional study, PLoS One, 2018, 13(3):e0192372, https://pubmed.ncbi.nlm.nih.gov/29584725/
4. Harikrishnan S, Sanjay G, Agarwal A, Kumar NP, Kumar KK, Bahuleyan CG, Vijayaraghavan G, Viswanathan S, Sreedharan M, Biju R, Rajalekshmi N, Nair T, Suresh K, Jeemon P, One-year mortality outcomes and hospital readmissions of patients admitted with acute heart failure: Data from the Trivandrum Heart Failure Registry in Kerala, India, Am Heart J, 2017, 189:193-199, https://pubmed.ncbi.nlm.nih.gov/28625377/
5. Harikrishnan S, Sanjay G, Ashishkumar M, Menon J, Rajesh G, Kumar RK, Pulmonary Hypertension Registry of Kerala (PROKERALA) - Rationale, design and methods, Indian Heart J, 2016, 68(5):709-715, https://pubmed.ncbi.nlm.nih.gov/27773412/
6. Harikrishnan S, Sanjay G, Anees T, Viswanathan S, Vijayaraghavan G, Bahuleyan CG, Sreedharan M, Biju R, Nair T, Suresh K, Rao AC, Dalus D, Huffman MD, Jeemon P, Clinical presentation, management, in-hospital and 90-day outcomes of heart failure patients in Trivandrum, Kerala, India, Eur J Heart Fail, 2015, 10.1002/ejhf.283, http://www.ncbi.nlm.nih.gov/pubmed/26011246?dopt=Abstract
7. Lopes AA, Barst RJ, Haworth SG, Rabinovitch M, Al Dabbagh M, Del Cerro MJ, Harikrishnan S, Repair of congenital heart disease with associated pulmonary hypertension in children, Pulm Circ., 2014, 4(2):330-41, http://www.ncbi.nlm.nih.gov/pubmed/25006452
8. Harikrishnan S Pillai, Ganapathi Sanjay, Heart failure in South Asia, Curr Cardiol Rev, 2013, 9(2):102-11, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682394/
9. Mohanan PP, Mathew R, Harikrishnan S, Huffman MD, Prabhakaran D, Presentation, management, and outcomes of 25 748 acute coronary syndrome admissions in Kerala, India, Eur Heart J, 2013, 34(2):121-9., http://www.ncbi.nlm.nih.gov/pubmed/?term=Presentation%2C+management%2C+and+outcomes+of+25+748+acute+coronary+syndrome+admissions+in+Kerala%2C+India%3A
10. Harikrishnan S, Bimal F, Ajithkumar V, Bhat A, Titus T, Tharakan J, Percutaneous treatment of congenital coronary arteriovenous fistulas, J Interv Cardiol, 2011, 24(3):208-15, http://www.ncbi.nlm.nih.gov/pubmed/21649734
11. Huffman MD, Rao KD, Pichon-Riviere A, Zhao D, Harikrishnan S, Calcagno JI, Caporale JE, A cross-sectional study of the microeconomic impact of cardio- vascular disease hospitalization in four LMIC, PLoS One, 2011, 6(6):, http://www.ncbi.nlm.nih.gov/pubmed/?term=A+cross-sectional+study+of+the+microeconomic+impact+of+cardio-+vascular+disease+hospitalization+in+four+LMIC
12. Cerro MJD, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S,, A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease, Pulm Circ, 2011, 1(2):286-98., http://www.ncbi.nlm.nih.gov/pubmed/?term=A+consensus+approach+to+the+classification+of+pediatric+pulmonary+hypertensive+vascular+disease
13. Harikrishnan.S, Ajithkumar V, Sivasankaran S, Percutaneous closure of RSOV, Eurointervention, 2010, 6(2):214-9., http://www.pcronline.com/eurointervention/login/?url_to=/eurointervention/download_pdf.php?issue=28th&article=34
14. S.Harikrishnan, Anil Bhat, J A Tharakan, T Titus, Ajith Kumar VK, S. Sivasankaran, Percutaneous Transvenous Mitral Commissurotomy Using Metallic Commissurotome, Journal of Invasive Cardiology, 2006, 18; 54-58., http://europepmc.org/abstract/MED/16446516
15. Harikrishnan, K. Nair, Percutaneous mitral valvotomy in juvenile mitral stenosis, Cath. and Cardiovasc intrevention, 2006, 67: 453-457, http://www.ncbi.nlm.nih.gov/pubmed/16489558
16. Harikrishnan.S, J M Tharakan, T Titus, Ajith kumar, Sivasankaran.S, Krishnamoorthy KM, Ventricular septal rupture following myocardial infarction - long term survival of patients who did not undergo surgery - single center experience, Acta Cardiologica, 2005, 60(4): 403-407, http://www.ncbi.nlm.nih.gov/pubmed/16128373
17. Harikrishnan.S, Anand Srinivasan, Sivasankaran.S, Krishnamoorthy KM, T Titus, Tharakan JM, Long Term Outcome of Patients Undergoing Balloon Mitral Valvotomy In Pregnancy, American journal of Cardiology, 2005, 95; 1504-1506, http://www.ncbi.nlm.nih.gov/pubmed/15950584
18. Harikrishnan Sivadasan Pillai, Sanjay Ganapathi:, Tobacco Cessation Approaches and Impact on CVD, Global Heart, 2005, Vol. 7, Issue 2,Pages 129, http://www.ncbi.nlm.nih.gov/pubmed/25691309
19. Anil Bhat , Harikrishnan. S, JM Tharakan, T.Titus, VK Ajith kumar , S.Sivasankaran, Francis Bimal, Comparison of percutaneous transmitral commissurotomy using Inoue balloon technique and metallic commissurotomy - immediate and short term follow up results of a randomised study, Am Heart J, 2002, 144:1074-80, http://www.researchgate.net/publication/10987866_Comparison_of_percutaneous_transmitral_commissurotomy_with_Inoue_balloon_technique_and_metallic_commissurotomy_Immediate_and_short-term_follow-up_resul
20. S. Harikrishnan, Jaganmohan Tharakan, T. Titus, Anil Bhat, S Sivasankaran, Francis Bimal, K R Shyam sunder, Central Pulmonary Artery Anatomy in Right Ventricular Outflow Tract Obstructions, International Journal of Cardiology, 2000, 73: 225-230, http://www.internationaljournalofcardiology.com/article/S0167-5273(00)00219-9/abstract

Review

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