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Dr. Cibin T. R.

2559 CIBIN

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Dr. Cibin T. R.
Associate Professor
Biochemistry

Phone number:

4178(O)

People - Biochemistry

Dr. Cibin T. R.

Academic Qualifications

  • Ph.D., Biochemistry, University of Kerala, Thiruvananthapuram. 2011.
  • M.Phil., Biochemistry, University of Kerala, Thiruvananthapuram. 2004.
  • M.Sc., Biochemistry, University of Madras, Chennai. 2002.
  • B.Sc., Biochemistry, University of Madras, Chennai. 2000.

Professional Record

  • Associate Professor, Department of Biochemistry, SCTIMST. July 2021 - till date
  • Assistant Professor, Department of Biochemistry, SCTIMST. June 2018 - June 2021
  • Project Scientist, Kerala University of Fisheries and Ocean Studies (KUFOS), Panangad, Kochi, Kerala, India. 2016-2018
  • Post Doctoral Scholar, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. 2014-2016
  • Post Doctoral Scholar, Case Western Reserve University, Cleveland, OH, USA 2011-2014
  • ICMR-Senior Research Fellow, Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India. 2008-2011
  • Junior Research Fellow, Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India. 2004-2008
  • Lecturer, Department of Biochemistry, Govt. College, Kariavattom, Thiruvananthapuram, Kerala, India. 2002

Awards

  • Best Research Poster Award at 11th Indian Fisheries and Aquaculture Forum, Central Institute of Fisheries Technology, Cochin, Kerala, India. 21-24 November 2017.
  • Best Research Poster Award at Research Showcase- 2014, Case Western Reserve University, Cleveland, Ohio, USA. 18 April 2014.
  • Research Paper entitled - UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation? published in Journal of Biological Chemistry showcased in National Eye Institute (NEI), US Govt. website. (Link: https://nei.nih.gov/news/briefs/uv_cataract)

Area of Interest

  • Role of Advanced Glycation Endproducts (AGEs) in Tissue Fibrosis.

Membership

  • Life member, Indian Science Congress Association, India
  • Life Member, Society of Biological Chemists, India
  • Life Member, Academy of Cardiovascular Sciences, India
  • Life Member, Kerala Academy of Sciences
  • Life Member, Kerala Numismatic Society, India

On-going Projects

  • Role of S100 proteins in Cardiac Fibrosis. Role: Principal Investigator. Funding: ICMR. 2022-2025
  • Genetic Architecture of Parkinson's Disease in India. Role: Co-Investigator. Funding: Michael J Fox Foundation, USA. 2019-2022

Projects Completed

  • AGE modification of basement membrane: Implications in neurodegenerative diseases. Role: Principal Investigator. Funding: SCTIMST Seed fund. 2019-2021
  • Development of Real-time PCR assay for detection of SARS-COV2. Role: Co-Investigator. Funding: SCTIMST-TDF. 2020-2021

Professional Experience

Training

  • Training programme on Quality Management Systems and Internal Audit in Medical Laboratories as per ISO 15189:2102. Duration: 4 days. 2019.

Presentations

  • TGFb2 mediated Epithelial to Mesenchymal Transition: Role of AGE-RAGE interaction. 12th Young Investigator Meeting (YIM) 2020 held from 14-18 February 2020 at Mahabalipuram, Chennai.

Invited talks

  • Kynurenines and AGE synthesis. International seminar on recent trends in Omics, Regenerative and Precision Medicine: Interface between Infectious and non-infectious diseases organized by Department of Zoology, University of Kerala, Trivandrum. 23 July 2022.
  • Gene editing in research. International seminar on Life Sciences organized by Department of Biotechnology, Government College, Kariavattom, Trivandrum. 04 March 2022
  • Gene Knockout, Knockdown and Knockin. Online Faculty Development Programme (FDP) organized by Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasaragod. 18 January 2022
  • Advanced Glycation Endproducts and Kynurenine Pathway. Webinar organized by GN Ramachandran Science Club, Mar Athanasios College of Advanced Studies Tiruvalla (MACFAST). 06 Jan 2021
  • Advanced Glycation Endproducts and Fibrosis. National Seminar on ‘Novel Prospects in Biotechnology’. Organized by Department of Botany and Biotechnology, AJ College of Science and Technology, Thiruvananthapuram. 7th November 2019.
  • Kynurenine-mediated ascorbic acid oxidation and Advanced Glycation Endproducts. National Seminar on ‘Recent Approaches in Biochemical Research’. Organized by Department of Biochemistry, University of Kerala, Thiruvananthapuram on 5th November 2019.
  • Glycation and Fibrosis. National Symposium on Advances in Biosciences (SEIB 2019). Organized by Inter-University Centre for Evolutionary and Integrative Biology, University of Kerala, Thiruvananthapuram.
  • Glycation and Fibrosis. National Seminar on Biomedical Research: Changing Paradigms across time. Organized by Department of Biochemistry, Govt. College, Kariavattom, Thiruvananthapuram. 1st February 2019.

Reviewer

  • Reviewer, PLOS One

Publications

Article

  1. Cibin T. Raghavan, Mi-Hyun Nam, Rooban B. Nahomi, Andrew J.O. Smith, Mina B. Pantcheva, Mareen Smuda, Micheal I. Wormstone, Marcus A. Glomb and Ram H. Nagaraj., AGEs in extracellular matrix promote the TGFb2-mediated epithelial to mesenchymal transition of lens epithelial cells: Implications for secondary cataracts., IMARS Highlights, 2019, 14(3): 14-17
  2. Cibin T. Raghavan and Ram H. Nagaraj, AGE-RAGE interaction in the TGFb2-mediated epithelial to mesenchymal transition of human lens epithelial cells., Glycoconjugate Journal, 2016, 33(4): 631-643, https://link.springer.com/article/10.1007/s10719-016-9686-y
  3. Cibin T. Raghavan, Mareen Smuda, Andrew J. O. Smith, Scott Howell, Dawn G. Smith, Annapurna Singh, Pankaj Gupta, Marcus A. Glomb, I. Michael Wormstone and Ram H. Nagaraj., Advanced Glycation Endproducts in Human Lens Capsule Promote the TGFb2-mediated Epithelial to Mesenchymal Transition of Lens Epithelial Cells: Implications for Posterior Capsule Opacification., Aging Cell, 2016, 15(3): 465-476, https://onlinelibrary.wiley.com/doi/abs/10.1111/acel.12450
  4. Ram H. Nagaraj, Rooban B. Nahomi, Niklaus Mueller, Cibin T. Raghavan, David Ammar and J. Mark Petrash., Therapeutic Potential of a-Crystallin., Biochemica et Biophysica Acta - General Subjects, 2016, 1860 (1 Pt B):252-257, https://www.sciencedirect.com/science/article/pii/S0304416515000926?via%3Dihub
  5. Thomas Holm, Cibin T. Raghavan, Rooban Nahomi, Ram H Nagaraj and Line Kessel., Effects of photobleaching on selected advanced glycation end products in the human lens., BMC Research Notes, 2015, 8(1):5, https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-0977-3
  6. Mareen Smuda, Christian Henning, Cibin T. Raghavan, Kaid Johar, Abhay R. Vasavada, Ram H. Nagaraj and Marcus A. Glomb., Comprehensive Analysis of Maillard Protein Modifications in Human Lenses: Effect of Age and Cataract., Biochemistry, 2015, 54 (15): 2500-2507, https://pubs.acs.org/doi/abs/10.1021/bi5013194
  7. Mikhail Linetsky*, Cibin T. Raghavan*, Kaid Johar, Vincent M. Monnier, XingJun Fan, Abhay R. Vasavada and Ram H. Nagaraj. *Equal Contributions, UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation., Journal of Biological Chemistry, 2014, 289(24):17111-17123, http://www.jbc.org/content/289/24/17111.full
  8. Michael A. DiMauro, Sandip K. Nandi, Cibin T. Raghavan, Rajiv Kumar Kar, Benlian Wang, Anirban Bhunia, Ram H. Nagaraj, and Ashis Biswas., Acetylation of Gly1 and Lys2 promotes aggregation of human gD-crystallin., Biochemistry, 2014, 53(46):7269-7282, https://pubs.acs.org/doi/abs/10.1021/bi501004y
  9. Gayathri Devi D, Cibin T. R and Annie Abraham, Bis (3, 5-diiodo-2, 4, 6-trihydroxyphenyl) squaraine photodynamic therapy induces in vivo tumor ablation by triggering cytochrome c dependent mitochondria mediated apoptosis., Photodiagnosis and Photodynamic Therapy, 2013, 10(4):510-517, https://www.sciencedirect.com/science/article/pii/S1572100013000537
  10. Rooban B. Nahomi, Benlian Wang, Cibin T. Raghavan, Oliver Voss, Andrea Doseff, Puttur Santhoshkumar and Ram H. Nagaraj., Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts., Journal of Biological Chemistry, 2013, 288(18) 13022-13035, http://www.jbc.org/content/288/18/13022.long
  11. Cibin T. R, Gayathri Devi D and Annie Abraham., Chemoprevention of two stage skin cancer in vivo by Saraca asoka, Integrative Cancer Therapies, 2012, 11(3) 279-286, http://journals.sagepub.com/doi/full/10.1177/1534735411413264
  12. Annie Abraham, Devi D. Gayathri, T. R. Cibin and D. Ramaiah, Two different approaches in skin cancer therapy: using a photosensitizer/a natural product, Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 2010, 757603. doi:10.1117/12.84, https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7576/1/Two-different-approaches-in-skin-cancer-therapy--using-a/10.1117/12.842245.short
  13. T. R. Cibin, Devi D. Gayathri, D. Ramaiah and Annie Abraham, Squaraine PDT induces oxidative stress in skin tumor of swiss albino mice., Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 2010, 75761P. doi:10.1117/12.84, https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7576/1/Squaraine-PDT-induces-oxidative-stress-in-skin-tumor-of-swiss/10.1117/12.842288.short?SSO=1
  14. Cibin T. R, Gayathri Devi D and Annie Abraham., Chemoprevention of skin cancer by the flavonoid fraction of Saraca asoka, Phytotherapy Research, 2010, 24(5):666-672, https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2950
  15. Rejiya C.S, Cibin T.R and Annie Abraham, Leaves of Cassia tora as a Novel Cancer Therapeutic - An in vitro study., Toxicology in Vitro, 2009, 23:1034-1038, https://www.sciencedirect.com/science/article/pii/S0887233309001386
  16. Gayathri Devi D, Cibin T. R, Ramaiah D and Annie Abraham, Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine: A novel candidate in photodynamic therapy for skin cancer models in vivo., Journal of Photochemistry and Photobiology B: Biology, 2008, 92: 153-159, https://www.sciencedirect.com/science/article/pii/S1011134408001218
  17. Gayathri Devi V, Biju P.G, Gayathri Devi D, Cibin T. R, Lija Y and Annie Abraham, Isolation of Robinetin from Adenanthera pavonina and its protective effects on perchlorate induced oxidative damage., Journal of Tropical Medicinal Plants, 2006, 7 (1): 111-117, -
  18. Lija Y, Biju P. G, Reeni A, Cibin T. R, Sahasranamam V and Annie Abraham., Modulation of Selenite Cataract by the Flavonoid Fraction of Emilia sonchifolia in Experimental Animal Models, Phytotherapy Research, 2006, 20: 1091-1095, https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2005
  19. Cibin T. R, Srinivas. G, Gayathri Devi. D, Priya Srinivas, Lija. Y and Annie Abraham, Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells., International Journal of Pharmacology, 2006, 2(5): 520-524, https://scialert.net/abstract/?doi=ijp.2006.520.524