Dr. G. Srinivas

Academic Qualifications

• PhD, Cancer Research ; Regional Cancer Centre, Thiruvananthapuram ; 2001
• MSc Medical Biochemistry ; JIPMER, Pondicherry ; 1994

Professional Record

• Scientist G & Head; July 2019 Onwards
• Scientist F & Acting Head, July 2018- June 2019
• Scientist F, July 2015- June 2018
• Scientist E, Oct 2014- June 2015
• ICMR International Fellow, Endocrinology, Diabetes, Metabolism and Nutrition; Mayo Clinic, Rochester, USA; Mar 2014- Sep 2014
• Scientist E, July 2012- Feb 2014
• Scientist D, July 2010- June 2012
• IUSSTF Research Fellow, Endocrinology, Diabetes, Metabolism and Nutrition ; Mayo Clinic, Rochester, USA ; July 2009- July 2010
• Scientist D, June 2008- July 2009
• Scientist C, Department of Biochemistry, June 2004- June 2008
• Scientist B, Division of Cancer Biology ; Rajiv Gandhi Centre for Biotechnology ; Sept 2000- May 2004
• Lecturer & Head, Dept of Biochemistry ; NSS College, Pandalam, Dec 1996- August 2000
• Junior Research Fellow (UGC), Division of Lab Medicine and Tumor Biology ; Regional Cancer Centre ; Oct 1994- Nov 1996

Awards

• Awarded the Japanese Travel Grant to participate and present a paper at the First Indo Japan Cancer Symposium held during July 24-26, 2023 at Cancer Research Institute, Kanazawa University, Japan.
• Awarded DST international Travel Grant to participate and present a paper at the 78th American Diabetes Association held during Jun 22-26, 2018, at Orlando, USA.
• Awarded Institutional Travel Grant for attending the 100th International Workshop on High Resolution Respirometry, O2k-Fluorometry and TPP, 2015 April 09-14 Schröcken, Vorarlberg, Austria
• Awarded UGC-CSIR/NET JRF-1993; MSc Second Rank- JIPMER-1994
• Awarded DST International Travel Grant to participate and present a paper in the "International Phytochemical Society of Europe symposium on Natural Products and Cancer Therapy" held at Naples, Italy during 22-26 September, 2008 and invited to participate and present a poster at "Ehrlich II- World Conference on Magic Bullets" held at Nurnberg, Germany during 3-5 October, 2008.

Area of Interest

• Clinical and Experimental Oncology, Regulation of Autophagy, Cardiac changes during diabetes, Risk factors in dementias

Fellowships

• Awarded the "IndoUS Science and Technology Forum Research Fellowship" (2009-10) for a period of one year to work Division of Endocrinology, Diabetes, Metabolism and Nutrition at Mayo Clinic, Rochester, USA.
• Indian Council for Medical Research (ICMR) International Fellowship (2013-14) to work at Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.

Membership

• Member, National Academy of Medical Sciences, India
• Life Member, Society for Biotechnologists (India)
• Life Member, International Academy of Cardiovascular Sciences (India Section)
• Life Member, International Society for Heart Research (India Section)
• Life Member, Society for Mitochondrial Research & Medicine, India
• Life member, Society for Evolutionary and Integrative Biology, India
• Member, Board of Studies (Medical Biochemistry), Kannur University, Kannur

On-going Projects

• Comparing mitochondrial function and dynamics in atrial tissue of patients undergoing Cardiopulmonary Bypass Surgery and Aortic Valve Repair replacement surgery; 2022-2025, 37.63 Lakhs, SERB
• Molecular mechanism of stress-induced NLRP3 activation and neuro inflammation by macrophages in presence of amyloid-beta in Alzheimer disease; 2021- 2024, 33.15 Lakhs, ICMR

Projects Completed

• 8

Desertations Supervised

• 11

Organisational Activities

Team

No. of Publications

• 60

Dissertations Supervised - Ph.D

• 11

Dissertations Supervised - M.Phil

• 3

Publications

Article

1. Mahalaxmi Ganjoo, Ashok Sivasailam, Arun Gangadharan, Srinivas Gopala., Albumin binds to uncoupler CCCP to diminish depolarization of mitochondria., Toxicology In Vitro., 2022, 80
2. Nandini Ravikumar Jayakumari, Raji Sasikala Rajendran, Harikrishnan Vijayakumar Sreelatha, Srinivas Gopala., Honokiol regulates mitochondrial substrate utilization and cellular fatty acid metabolism in diabetic mice heart., Eur J Pharmacol,, 2021, 896:
3. Raji Sasikala Rajendran, Nandini Ravikumar Jayakumari, Ashok Sivasailam, Anand Chellappan Reghuvaran, Vivek Velayudan Pillai, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha, Shankarappa Manjunatha, Srinivas Gopala., Diminished substrate-mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats., IUBMB,, 2021, 73: 676-689, .
4. Dhanya Krishnan, Ramsekhar Menon, Srinivas Gopala., SHARPIN: Role in Finding NEMO and in Amyloid Beta Clearance and Degradation (ABCD) Pathway in Alzheimer���s Disease?, Cellular and Molecular Neurobiology, 2022, 42: 1267-1281,
5. Anand CR, Bhavya Bharathan, Jayakumar K, Harikrishnan VS, Srinivas Gopala., Inorganic nitrite alters mitochondrial dynamics via Drp1 activation without modifying cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia., Toxicology In Vitro, 2021, 70
6. Bhavya Bharathan, H V Easwer, George C Vilanilam, Sreelakshmi K, Anand CR, Madhusoodanan UK, Leena Issac, Padmakrishnan CJ, Girish R Menon, Krishnakumar K, Rajalakshmi, Deepti AN, Srinivas Gopala., MutT Homolog 1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible Factor1 alpha., Life Sciences, 2021, 264:
7. Revathy Nadhan, Dipyaman Patra, Neethu Krishnan, Arathi Rajan, Srinivas Gopala, Dashnamoorthy Ravi, Priya Srinivas., Perspectives on mechanistic implications of ROS inducers for targeting viral infections., Eur J Pharmacol, 2020, 890:
8. Gurpreet Singh, Srinivas Gopala, Jyothi EK, Gayathri LK, Rakhal Gaitonde, Biju Soman., The Sree Chitra experience in containing the first outbreak of Covid-19 in a healthcare setting in India., Indian Journal of Public Health,, 2020, 64: S241-242,
9. Soumya Krishnamoorthy, Deepa Damayanthi, Srinivas Gopala, Rejith Paul, Sylaja PN., High-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 in predicting recurrence and severity of stenosis in symptomatic intracranial atherosclerotic disease., Current Proteomics,, 2020, 17: 1-6,
10. Nandini R J, Raji S R, Ashok S, Surabhi SV, Saurabh N, Manjunatha S, Vivek V Pillai, Jayakumar K, Srinivas Gopala., Impaired substrate mediated cardiac mitochondrial complex 1 respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic heart., J of Diabetes,, 2020, 12: 542-555,
11. Dhanya Krishnan, Ramsekhar Menon, Mathuranath PS, Srinivas Gopala., A novel role for SHARPIN in A��- phagocytosis and inflammation by peripheral blood derived macrophages in Alzheimer���s disease., Neurobiology of Aging,, 2020, 93: 131-141,
12. Rizwan Kalani, Soumya Krishnamoorthy, Deepa Damayanthi, Srinivas Gopala, Dorairaj Prabhakaran, David Tirschwell, P. N. Sylaja., Apolipoproteins B and A1 in ischemic stroke subtypes., Journal of Stroke and Cerebrovascular Diseases, 2020, 29: 4: 104670,
13. Bhavya Bharathan, Anand CR, Madhusoodanan UK, Rajalakshmi P, Krishnakumar K, H V Easwer, Deepti AN, Srinivas Gopala., To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 and 2-Hydroxy Glutarate in Gliomagenesis and Treatment Outcome in Glioma., Cellular and Molecular Neurobiology, 2020, 40: 53-63,
14. Jairani PS, Aswathy PM, Dhanya Krishnan, Ramsekhar N Menon, Joe Varghese, Mathuranath PS, Srinivas Gopala., Apolipoprotein E Polymorphism and Oxidative Stress in Peripheral Blood- Derived Macrophage-Mediated Amyloid-Beta Phagocytosis in Alzheimer���s Disease Patients., Cellular and Molecular Neurobiology, 2019, 39: 355-369,
15. Gregory N Ruegsegger, S Manjunatha, Priska Summer, Srinivas Gopala, Piotr Zabeilski, Surendra Dasari, Patrick M Vanderboom, Ian R Lanza, Katherine A Klaus, K Sreekumaran Nair., Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes, FASEB J, 2019, 33: 4458-4472,
16. Padmakrishnan CJ, Easwer HV, Girish Menon R, Krishna Kumar K, Suresh Nair, Bhavya Bharathan, Neelima Radhakrishnan and Srinivas Gopala, In vitro neurosphere formation correlates with poor survival in glioma, IUBMB Life, 2019, 71: 244-253
17. Padmakrishnan CJ, Easwer HV, Vinod Vijayakurup, Girish Menon R, Suresh Nair,Srinivas Gopala, High LC3/Beclin expression correlates with poor survival in glioma: a definitive role for autophagy as evidenced by, Pathology Oncology Research, 2017, NA(e-article ahead of pri
18. P M Aswathy, P S Jairani, Joe Verghese, Sheelakumari R, Srinivas Gopala, Priya Srinivas , P S Mathuranath, Progranulin mutation analysis: Identification of one novel mutation in exon 12 associated with frontotemporal dementia, Neurobiology of Aging, 2016, 39: 218e1-218.e3, https://www.ncbi.nlm.nih.gov/pubmed/26724960
19. Piotr Zabielski, Ian R. Lanza,, Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice, Diabetes, 2016, 65: 561-573, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764144/
20. P S Jairani, P M Aswathy,, Interaction with MAPT H1/H1 haplotype increases dementia risk in APOE I?4 carriers in a population of southern India, Dementia and Geriatric Cognitive Disorders, 2016, 42: 255-264, https://www.ncbi.nlm.nih.gov/pubmed/27705964
21. Piotr Zabielski, Agnieszka Blachnio-Zabielska, Ian Lanza,, Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice, AJP-Endocrinology and Metabolism, 2014, 306: E529-546
22. Vinod Vijayakurup, Spatafora Carmela,, PCBL, a benzo[, Molecular Biology Reports, 2014, 41: 85-94
23. P M Aswathy, P S Jairani, Joe Verghese,, MAPT, Neurobiology of Aging, 2014, 45:, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031455/
24. Vinod Vijayakurup, Padmakrishnan CJ, Bejoy Vijayan,, a??How can I halt theea??? The puzzles invoved in autopahgic inhibition, Pharmacological Research, 2014, 82: 1-8, http://www.sciencedirect.com/science/article/pii/S1043661814000280
25. Nandini Ravikumar Jayakumari, Anand Chellappan Reghuvaran, Raji Sasikala Rajendran, Vivek Velayudhan Pillai, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha,, Are nitric oxide-mediated protein modifications of functional significance in diabetic heart? ye'S, -NOa??, wha??Y-NOa??t?, Nitric Oxide, 2014, 43: 35-44, https://www.ncbi.nlm.nih.gov/pubmed/25153035
26. Srinivas Gopala, The curious case of the disappearance of a??peaks of Himalayasa?? during an aeroplane ride, Health Sciences, 2013, 4: 1-14
27. Vinod Vijyakurup, Spatafora Carmela, Daquino Carmelo, Tringali Corrado, Priya Srinivas,, Phenethyl caffeate benzo[, Life Sciences, 2012, 91: 1336-1344, http://europepmc.org/abstract/med/23123449
28. Suboj Babykutty, Priya Prasanna Sathiadevan, Nandini RJ, Suresh Kumar MA, Mangalam S Nair, Priya Srinivas,, Nimbolide retards tumor cell migration, invasion and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA binding activity of NF-I?B in colon cancer cells, Moleclar Carcinogenesis, 2012, 51: 475-490
29. Priya S, Suboj Babykutty, Deepak Roshan V G, Rakesh S Nair, Priya Srinivas,, Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-I?B, European Journal of Pharmaceutical Sciences, 2012, 45: 581-591
30. Priya S, Suboj Babykutty, Priya Srinivas,, Aloe emodin induces G2/M cell cycle arrest, and apoptosis via activation of caspase- 6 in human colon cancer cells, Pharmacology, 2012, 89: 91-98
31. Thasni KA, Ratheeshkumar T, Rojini G, Sivakumar KC, Rakesh Sathish Nair,, Structure activity relationship of plumbagin in BRCA1 related cancer cells, Molecular Carcinogenesis, 2012, 51: 475a??490
32. Suboj Babykutty, Priya S, Priya Srinivas, Asha S Nair, K Chandramohan,, Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways, Clinical and Experimental Metastasis, 2012, 29: 471-492, http://europepmc.org/abstract/med/22419013
33. Bejoy Vijayan,, LRRK2 G2019S mutation does not contribute to Parkinsona??s disease in South India, Neurology India, 2011, 59: 157-160
34. Robert M,, Tau and Taupathies, Neurochemical Mechanisms in Disease- Advances in Neurobiology, 2010, 633-667
35. Thankappan KR, Bela Shah, Prashant Mathur, Sarma PS,, Risk factor profile for chronic non-communicable diseases: Results of a community-based study in Kerala, India, Indian J Med Res, 2010, 131, 53-63
36. Jaleel A, Henderson GC, Madden BJ, Klaus KA, Morse DM,, Identification of de novo synthesized and relatively older proteins- Accelerated oxidative damage to de novo synthesized ApoA-1 in type 1 diabetes, Diabetes, 2010, 59, 2366-2374
37. Suboj Babykutty, Jose Padikkala, Prasanna Sathiadevan, Vinod Vijayakurup, Thasni K, Apoptosis induction of, Afr J Trad CAM, 2009, 6(1): 9-16
38. Sreekala Nair, Raghu Ram K Nair, Priya Srinivas,, Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway, Mol Carcinog, 2008, 47 (1): 22-33
39. Aghila Rani, K Jayakumar,, Isolation of ckit-positive cardiosphere-forming cells from human atrial biopsy, Asian Cardiovasc Thorac Ann, 2008, 16:50-56
40. Thasni KA, Rakesh S, Rojini G, Ratheeshkumar T,, Estrogen dependent cell signaling and apoptosis in BRCA1 blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents, Annal Oncol, 2008, 19: 696-705
41. Thasni KA, Rojini G, Rakesh S. Nair, Ratheeshkumar T, Mani Shankar Babu,, Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status, . Eur J Pharmacol, 2008, 588: 158-164
42. Santhosh K, Thomas B, Varma L, Sandhyamany S, Kesavadas C, Appukuttan PS,, Metabolite signature of developmental foregut cyst on in vivo and in vitro (1)H MR spectroscopy, J Magn Reson Imaging, 2008, 28(2)
43. Srinivas G, Medical Research in Kerala, Kerala, Fifty years and beyond, 2007, 217-241
44. Gopal Srinivas, Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent, Med Res Rev, 2007, 27 (5): 591- 608
45. Cibin TR,, Antioxidant and antiproliferative effects of flavanoids from, Int J Pharmacol, 2006, 2: 520-525
46. Srinivas G, Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase 9., Eur J Pharmacol, 2004, 473: 117-125
47. Suby Oommen, Ruby John Anto,, Allicin (from garlic) induces apoptosis in human cervical cancer cells, Eur J Pharmacol, 2004, 485: 97-103
48. Gopal Srinivas, Antisense blocking of BRCA1 enhances the sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells, Mol Carcinog, 2004, 39(1): 15-25
49. Priya Srinivas, Gokul Gopinath, Asoke Banerji, Abhilash Dinakar,, Plumbagin induces reactive oxygen species mediated apoptosis in human cervical cancer cells, Mol Carcinog, 2004, 40(4): 201-211
50. Srinivas G, In vitro drug sensitivity and apoptosis induction in newly diagnosed pediatric acute lymphoblastic leukemia: correlation with overall survival, Pediatr Hematol Oncol, 2004, 21:465-73
51. Srinivas G, Mutant p53 protein, Bcl-2/bax ratios and apoptosis in pediatric acute lymphoblastic leukemia, J Cancer Res Clin Oncol, 2000, 126: 62-67
52. Srinivas G, Clinical relevance of programmed cell death in pediatric acute lymphoblastic leukemia, Research Bulletin of the Panjab University, 1999, 49: 267-277
53. Srinivas G, Bcl-2 protein and apoptosis in pediatric acute lymphoblastic leukemia, Int J Mol Med, 1998, 1: 755-759
54. Srinivas G, Tumor proliferative compartment, multidrug resistant gene product and apoptosis regulatory p53 and bcl-2 in pediatric acute lymphoblastic leukemia, Oncol Rep, 1997, 4: 1083-1087
55. Kesari L, Radhakrishnan R, Bhanuamthy A, Ravi D,, Expression of epidermal and transforming growth factors in pancreatic cancer, Oncol Rep, 1996, 3: 963-966
56. Sreelekha TT, Kusumakumary P,, Argyrophilic Nucleolar Regions (AgNORs) in pediatric acute lymphoblastic leukemia, Cancer Lett, 1996, 108: 87-91

Book Chapter

1. Mahalaxmi Ganjoo, Ashok Sivasailam, Varghese T Panicker, Srinivas Gopala., Mitochondrial dynamics and mitophagy in heart: Role in diseases and interventional opportunities, Modulation of Oxidative Stress in Heart Diseases, 2019, Edited by Prof. Sajal Chakraborti, Dr. Naranjan S Dhalla, Prof. Madhu Dikshit, and Dr. Nirmal Kumar
2. Robert M, Srinivas G, Mathuranath PS, Tau and Taupathies, Neurochemical Mechanisms in Disease- Advances in Neurobiology., 2010, Edited by: Abel Lajtha. NewYork: Springer Verlag Publications; 2010: 633-667.

Chapter

1. Srinivas G and CC Kartha., Medical Research in Kerala, Kerala, Fifty years and beyond., 2007, Edited by: CC Kartha. Thiruvananthapuram: Gautha Books; 2007: 217-241.